Words similar to minimization
Example sentences for: minimization
How can you use “minimization” in a sentence? Here are some example sentences to help you improve your vocabulary:
Since liver metabolism accounts for greater than 95% of ethanol removal, it is assumed that the liver is the only site of ethanol elimination [ 19 ] . The liver metabolic constants (Vm = 2.1 millimoles/min for 80 Kg man, Km = 0.04 mM) were adjusted using the Powell minimization procedure of PKQuest to give the best fit to the data.
It is for practical reasons not possible to do this minimization over every combination, so the suggestion is to estimate the criterion over a lattice of (α, S 0 ) values and pick the best combination.
The flexible ligand / grid receptor docking algorithm implemented in ICM was applied, with ECEPP/3 force field and MMFF partial charges for the ligand, and hydrophobic, electrostatic, hydrogen-bond and surface potential maps for the receptor [ 18 19 10 ] . Further optimization with flexible ligand and full atom representation of the receptor was carried out by local energy minimization, where all side-chains within 6 A of the ligand were flexible [ 18 ] . When docking was performed in the presence of a water molecule, the later was included in the grid representation of the receptor, and was mobile during full-atom local minimization.
The energy difference of 0.05 Kcal/mol between two successive structures during both minimization steps was used as the termination criterion.
One hundred steps of energy minimization of the protein-ligand-water complex were initially performed, followed by 10 ps MD simulation at 300 K, with an atom-based shifted distance-dependent dielectric constant, ε = 4r; a switch function on van der Waals interaction, and a time step of 1 femtosecond (fs).
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