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Example sentences for: mimics
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Cross-hybridization was observed between a subset of HPV target mimics and the capture and signal probes.
Although the mechanisms through which adrenalectomy acts to reverse obesity is not entirely clear, it is plausible that the mechanisms entail enhanced hypothalamic POMC production [ 6 ] . Hypothalamic POMC mRNA is reduced in several forms of obesity [ 18 19 20 ] . Conversely, reversal of obese phenotypes by adrenalectomy is associated with a restoration of hypothalamic POMC mRNA tone in leptin-deficient ob/ob mice [ 6 ] . Furthermore, the melanocortin agonist MTII (which mimics the key anti-obesity product of POMC, alpha-MSH) reduces body weight in diet-induced obesity [ 21 ] . On the other hand, the effect of diet-induced obesity on hypothalamic POMC mRNA is somewhat complex and may depend on the genetic background [ 22 23 ] , and duration of the diet [ 24 25 ] or composition [ 23 ] of the diet.
Similarly, mesothelin expression was induced by Li+, an inhibitor of GSK-3β, that mimics Wnt-1.
Specifically, Wnt-5a expression inhibits ectopic Wnt-8 induction of secondary axis formation in Xenopus embryos [ 11 ] . Supportingly, the endogenous expression of Wnt-5a maintains C57mg cells in a normal growth state since anti-sense Wnt-5a mimics Wnt-1 transformation of C57mg cells [ 12 ] . This data suggests that Wnt-1 and Wnt-5a work in an opposing manner in some cellular contexts.
This dose-dependent profile of expression closely resembles the response achieved by increasing concentrations of Hh protein [ 22 23 24 ] , demonstrating that the Hh agonist mimics the concentration-dependent inductive activity of Hh on neural precursors.
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