Words similar to mifepristone

Example sentences for: mifepristone

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Nevertheless, pharmacological antagonism of glucocorticoid (type II) receptor by mifepristone (RU486) was reported to reverse high fat diet-induced obesity [ 14 ] . Since diet-induced obesity does not entail elevated glucocorticoid levels [ 15 16 17 ] , this result suggests that reduction of glucocorticoid levels would reverse obesity even when glucocorticoid levels are not elevated.
RU486 (Mifepristone) has shown remarkable antiglucocorticoid and antiprogestrone activities both in vitro and in vivo [ 1 2 ] . This compound has a high affinity for ligand binding sites of both receptors [ 1 2 ] . Current clinical uses of RU486 are limited to its function as a progestrone antagonist [ 1 2 ] , where it was approved in France in 1988, and recently in the USA as a means to induce early termination of pregnancy [ 1 2 3 ] .