Words similar to midgestation
Example sentences for: midgestation
How can you use “midgestation” in a sentence? Here are some example sentences to help you improve your vocabulary:
The history of the T locus began with the discovery in 1927 of a semi-dominant mutation in mice, named Brachyury , or T for tail, that affects both embryonic viability in homozygotes and tail development in heterozygotes [ 1 ] . This original T allele represents a deletion spanning 160-200 kb (reviewed in [ 2 ] ), the developmental effects of which have been well characterized [ 3 4 5 6 7 8 ] . Homozygous mutant embryos show a developmental failure of the notochord and posterior mesoderm, and die at midgestation.
Nagy et al demonstrated that embryos and mice could be derived solely from R1 ES cells by aggregating them with tetraploid embryos [ 7 8 ] . Although we were able to repeat these data using R1 ES cells we were unable to generate midgestation embryos from E14TG2a-derived strains of hprt negative ES cell lines using the same approach [ 9 10 11 ] . We believed it was unlikely that Hprt itself was required to generate ES cell-derived embryos because hprt knockout mice are viable and fertile [ 12 ] . E14TG2a-derived ES cell lines contain a large spontaneous deletion encompassing 55 kb of the hprt locus [ 13 ] . Therefore, it seemed possible that sequences within this region were necessary to maintain ES cell pluripotency.
All embryos exhibited characteristic features of midgestation stages of development including normal rostral-caudal patterning, beating hearts, normal limb formation including the formation of fingers.
5 midgestation embryo, the extraembryonic yolk sac, and the placenta.
Loading...