Words similar to micturition
Example sentences for: micturition
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Blockade of the external urethral sphincter in anesthetized rats results in a disappearance of the HFO from the bladder pressure recording as well as a disappearance of the bursting pattern of the EUS EMG observed during HFO [ 26 27 28 ] . In addition, there is a decreased ability of the bladder to empty as evidenced by a decreased micturition volume and an increased residual volume [ 26 27 29 ] . Therefore, inhibition of the external urethral sphincter, as was the case for the two neuroleptics in the present study and also for clozapine in our earlier study [ 7 ] , might provide an important mechanism by which the bladder is rendered less effective in emptying and therefore altering other urodynamic variables resulting in decreased micturition volume and increased residual volume in rats.
In the case of intracerebroventricular administration, 0.5 nmoles of clozapine decreased the micturition volume to 0.11 ± 0.02 ml compared to 0.16 ± 0.018 ml after vehicle (Fig 3B).
The exact receptor types (or combination of receptor types) responsible for clozapine's central effects on micturition were not investigated in the present study.
Therefore, central effects of clozapine in controlling micturition volume are likely.
Given the modest role of serotonin receptors in micturition in anesthetized rats, it remains to be determined whether the effects observed here were due to anti-serotonergic effects of these neuroleptics.
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