Words similar to micturition
Example sentences for: micturition
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At 10 mg/kg of risperidone, the micturition volume was 0.19 ml (± 0.036) which was not statistically different from the control values.
Although the effect of prostatic enlargement on the bladder is primarily mechanical it is possible that in time it might also alter the neuronal circuitry that mediates micturition.
Blockade of the external urethral sphincter in anesthetized rats results in a disappearance of the HFO from the bladder pressure recording as well as a disappearance of the bursting pattern of the EUS EMG observed during HFO [ 26 27 28 ] . In addition, there is a decreased ability of the bladder to empty as evidenced by a decreased micturition volume and an increased residual volume [ 26 27 29 ] . Therefore, inhibition of the external urethral sphincter, as was the case for the two neuroleptics in the present study and also for clozapine in our earlier study [ 7 ] , might provide an important mechanism by which the bladder is rendered less effective in emptying and therefore altering other urodynamic variables resulting in decreased micturition volume and increased residual volume in rats.
In cats, serotonin antagonists caused a decrease in bladder capacity [ 43 ] however in anesthetized rats, serotonin antagonism did not have an effect on micturition [ 44 ] . Recently, a selective 5-HT1A receptor antagonist (WAY-100635) was reported to inhibit bladder contractions in rats [ 45 ] yet another report only observed an increase in the pressure threshold [ 46 ] . Olanzapine and risperidone have only low to modest affinity for the 5-HT1A receptor, and higher affinities for the 5-HT2A and 5-HT2C receptors [ 11 12 ] . Serotonin 5-HT2 and 5-HT3 receptors facilitate pudendal reflexes in the cat [ 47 48 ] , therefore it is possible that antagonism of these receptors may block the EUS in the anesthetized rat.
Both neuroleptics markedly decreased the micturition volume, expulsion time, and amplitude of the HFO while residual volume increased.
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