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Example sentences for: micrornas
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This view of the evolutionary history of RDRPs is compatible with the presence of RDRP homologs in phages and with their role in replicating microRNAs (potential relics of the RNA world) during PTGS in eukaryotes.
All 23 of the known microRNAs in Drosophila are located precisely in the Release 3 genome.
One class of substrates of the extant eukaryotic RDRPs are small RNAs, such as microRNAs and stRNAs [ 84 85 86 87 88 89 90 ] , and analogous small RNAs have been identified in bacteria [ 91 92 93 94 ] . Given that small RNAs are likely to have been abundant in the hypothetical ancient RNA world, RDRPs might have been involved in the replication of such RNAs since an early stage of evolution.
MicroRNAs were aligned by BLASTN analysis; a single exact match was found for each of the microRNAs listed in FlyBase.
Our collective ignorance of the totality of non-coding RNA genes was laid bare by recent work on microRNAs (miRNAs), an abundant family of 21-22 nucleotide non-coding RNAs [ 2 3 ] . The founding members of this family, lin-4 and let-7, were identified through forward analysis of extant Caenorhabditis elegans mutants [ 4 5 ] . Both of these RNAs are post-transcriptional regulators of developmental timing that function by binding to the 3' untranslated regions (3' UTRs) of target genes [ 5 6 7 8 ] . Although they were long regarded as genetic curiosities possibly specific to nematodes, let-7 was subsequently found to be broadly conserved across bilaterian evolution [ 9 ] and miRNA genes are now recognized as a pervasive and widespread feature of animal and plant genomes [ 10 11 12 13 14 15 16 ] .
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