Words similar to microenvironment
Example sentences for: microenvironment
How can you use “microenvironment” in a sentence? Here are some example sentences to help you improve your vocabulary:
The results presented in this study suggest that sub-lethal radiation is effective in augmenting adoptive anti-tumor immunity in the Rip1-Tag2 model, underscoring the potential value of perturbing the tumor microenvironment as well as the lymphoid compartment to enhance anti-tumor immunity.
has shown that this reduced proliferation is not intrinsic to Rag mutant thymocytes, but rather is secondary to thymic microenvironment defects in Rag mutants [ 37 ] . Our results show that at fetal stages, Rag mutant thymocytes have a proliferation profile that is much more similar to wild type thymocytes at the same stage, with less than a 2-fold difference in the percentage of proliferating cells at any stage.
The dominance of IFN-γ over RANKL, which we observed in vitro (1 ng IFN-γ counteracts 200 ng RANKL when simultaneously administered), probably allows this macrophage activation to occur even in the presence of RANKL expressed on circulating, activated T cells [ 20 40 ] . In the bone microenvironment, however, more abundant RANKL produced by osteoblasts/stromal cells may influence certain monocytes to commit to the osteoclast lineage [ 41 42 ] .
Thus, the early effects of IL-2 administration are more associated with an inflammatory modulation of the tumor microenvironment rather than with specific migration, activation and/or proliferation of immune cells at the tumor site.
Since the 'seed and soil' hypothesis of Paget in the 19th century [ 1 ] , it has been understood that the microenvironment, or 'soil,' surrounding the tumor 'seed' plays a critical part in its development.
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