Words similar to mevalonate

Example sentences for: mevalonate

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In further support of a role for isoprenoids, we were able to demonstrate that supplementation of cells with mevalonate abolished statin-activated shedding (see Figure 4).
As predicted by this model, we observed that statin-activated shedding was abolished by adding mevalonate.
Therefore, the addition of mevalonate would be predicted to antagonize statin action via the isoprenoid pathway, by relieving statin-induced mevalonate deficiency.
It has been speculated that an abnormality of translocation of 3-MGC acid across the mitochondrial membrane may be the source of 3-MGC aciduria in these patients [ 23 ] . The link between 3-MGC aciduria and mitochondrial dysfunction may involve failure of mitochondrial uptake of 3-MGC acid or potentially defective ubiquinone biosynthesis leading to increased levels of mevalonate in the mevalonate shunt pathway with subsequent increased synthesis of 3-MGC acid [ 27 ] .
Since FTI-1 acts downstream of HMGCoA reductase, the stimulatory effect of FTI-1 on sAPP α shedding would not be predicted to be modified by mevalonate supplementation.