Example sentences for: mesothelin

How can you use “mesothelin” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • On the other hand, PMA treatment of C57mg cells elevated SL-1 transcript levels 6-fold but not mesothelin (Figure 2, right panel).

  • Mesothelin, a potential tumor serum marker, was up-regulated by Wnt-1 and down-regulated by Wnt-5a.

  • Whether mesothelin and SL-1 are direct targets of Wnt-1 and Wnt-5a, respectively, and whether alterations in their expression are responsible for the observed phenotypic changes in Wnt-5a/Rfz-2/C57mg cells, has yet to be determined.

  • Interestingly, mesothelin expression is induced in lung, ovarian, and pancreatic carcinomas where constitutive activation of Wnt signaling is caused by stabilizing mutations in beta-catenin [ 27 28 41 42 43 44 ] . The induction of mesothelin in these carcinomas may be due to misregulation of Wnt signaling as are other targets of the Wnt pathway, c-myc and cyclin D1.

  • Similarly, mesothelin expression was induced by Li+, an inhibitor of GSK-3β, that mimics Wnt-1.


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