Words similar to mesothelin

Example sentences for: mesothelin

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One gene, mesothelin, exhibited a 3-fold induction in C57mg cells treated with the Wnt-1 but not the Wnt-5a secreting 293T cells (Figure 1, panel A).
The secreted form has been referred to as megakaryocyte potentiating factor (MPF) for its ability to stimulate the megakaryocyte colony forming activity of murine IL-3 in mouse bone marrow cell culture [ 23 24 ] . Mesothelin expression is induced in a variety of cancers including ovarian, pancreatic, lung, and cervical cancer [ 25 26 ] . The soluble portion of mesothelin has drawn attention as a potential serum tumor marker since it is highly over-expressed in patients with ovarian carcinomas and pancreatic adenocarcinomas [ 27 28 ] .
We focused on two genes, mesothelin and SL-1, whose regulation by Wnts was reproducible using a variety of methods to activate the Wnt signaling pathways.
Whether mesothelin and SL-1 are direct targets of Wnt-1 and Wnt-5a, respectively, and whether alterations in their expression are responsible for the observed phenotypic changes in Wnt-5a/Rfz-2/C57mg cells, has yet to be determined.
Similarly, mesothelin expression was induced by Li+, an inhibitor of GSK-3β, that mimics Wnt-1.