Words similar to mesothelin

Example sentences for: mesothelin

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Mesothelin is markedly over-expressed in a variety of cancers derived from tissues of the mesothelium, including lung, cervix, and pancreas.
Interestingly, Wnt-5a down-regulated mesothelin expression, perhaps through antagonism of endogenous Wnt/beta-catenin signaling.
The secreted form has been referred to as megakaryocyte potentiating factor (MPF) for its ability to stimulate the megakaryocyte colony forming activity of murine IL-3 in mouse bone marrow cell culture [ 23 24 ] . Mesothelin expression is induced in a variety of cancers including ovarian, pancreatic, lung, and cervical cancer [ 25 26 ] . The soluble portion of mesothelin has drawn attention as a potential serum tumor marker since it is highly over-expressed in patients with ovarian carcinomas and pancreatic adenocarcinomas [ 27 28 ] .
We focused on two genes, mesothelin and SL-1, whose regulation by Wnts was reproducible using a variety of methods to activate the Wnt signaling pathways.
One gene, mesothelin, exhibited a 3-fold induction in C57mg cells treated with the Wnt-1 but not the Wnt-5a secreting 293T cells (Figure 1, panel A).