Example sentences for: meropenem

How can you use “meropenem” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • also reported stopped-flow fluorescence studies when using cefaclor and meropenem as substrates, and K S values for these substrates were reported to be 710 ± 180 and 272 ± 112 μM, respectively [ 40 ] . However in our hands, the rates of substrate hydrolysis were so fast when using wild-type L1 that we could not use substrate concentrations high enough to saturate the enzyme.

  • With these two substrates, there was a 19-fold and 45-fold decrease in the k cat values when using biapenem and meropenem, respectively (Table 5).

  • The k cat values exhibited by these mutants for all substrates also differed by less than a factor of 4, except when biapenem and meropenem were used as substrates for the N233D mutant.

  • Instead, we predict that the insertion of an aspartic acid into the active site at position 224 results in a change in the hydrogen bonding network in L1; this hydrogen bonding network is extensive in all metallo-β-lactamases that have been characterized crystallographically [ 37 42 44 45 48 49 62 63 ] . The N233D mutant also exhibited greatly reduced k cat values for biapenem and meropenem but not for imipenem or any of the other substrates tested.

  • Imipenem, meropenem, and biapenem were generously supplied by Merck, Zeneca Pharmaceuticals, and Lederle (Japan), respectively.


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