Words similar to mendelian
Example sentences for: mendelian
How can you use “mendelian” in a sentence? Here are some example sentences to help you improve your vocabulary:
Typical resolution of the BXN set for mapping a Mendelian trait is 1-2 cM.
5) [ 20 ] ; type III 3-MGC aciduria (Costeff optic atrophy syndrome) (Mendelian Inheritance in Man database *258501) was described in patients of Iraqi-Jewish origin with bilateral optic atrophy accompanied in some by movement disorders and caused by mutations in the OPA3 gene [ 21 22 ] ; and type IV 3-MGC aciduria (Mendelian Inheritance in Man database *250951) presents with moderate to severe neurological disease, cardiac, ophthalmic, hepatic, and renal symptoms and it has been associated with mitochondrial disorders (Pearson syndrome, mitochondrial DNA depletion) or multiple respiratory chain defects [ 23 24 25 26 ] . This group does not have a defined primary biochemical or molecular defect.
Currently, several risk factors have been identified including cigarette smoking, arterial hypertension, gender, aging, atherosclerosis and heavy alcohol consumption [ 9 10 11 12 ] . Initial indications of a genetic component were based on collections of case reports that suggested that IAs are associated with some rare simple Mendelian disorders, e.g. autosomal dominant polycystic kidney disease, Ehlers Danlos syndrome type IV and the Marfan syndrome [ 13 ] . More recent systematic prevalence estimates indicate either absence of association or markedly reduced prevalence of IA among patients with rare simple Mendelian disorders [ 14 15 ] . Also, genetic analyses of genes known to cause some simple Mendelian disorders have proven negative for collections of patients with IA [ 16 17 ] . The familial occurrence of IAs not associated with known simple Mendelian disorders was first noted in 1942 [ 18 ] and, since then, nearly one hundred case reports and review articles have been published.
Both studies use the same key exclusion criteria; for example, both studies exclude iatrogenic and vasospastic ischemic stroke patients and exclude the same mendelian and mitochondrial disorders.
Cardiac conduction disturbance has also been recognized in the mitochondrial cytopathy, Kearns-Sayre syndrome (Mendelian inheritance in Man database *530000), characterized as progressive external ophthalmoplegia and retinopathy [ 16 ] . Clinical manifestations of cardiac disease occur in 57% of patients with Kearns-Sayre syndrome [ 17 ] . The complete AV block in Kearns-Sayre syndrome may also be associated less commonly with ventricular tachycardia, torsade de pointes and ventricular fibrillation as the ultimate and often fatal stage of the condition [ 18 ] . However, to our knowledge, ventricular tachycardia as a presenting feature has not been described in the context of mitochondrial cytopathies in the neonatal period.
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