Example sentences for: mdr

How can you use “mdr” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • In metastatic breast cancer, the development of a MDR phenotype is primarily responsible for insensitivity to a new drug [ 2].

  • If a similar modulation of the MDR phenotype occurs in vivo , then the duration of treatment with NOM becomes important.

  • For MDR1, GSTπ and TopoIIα genes, after an initial denaturation at 94°C for 1.5 min, 30 cycles of PCR amplification were performed, each cycle consisting of a denaturing step of 94°C for 1.5 min, annealing at 54°C for 1 min, and extension at 72°C for 3 min, followed by a final step at 72°C for 10 min.

  • A possible reversal mechanism was explored by studying the cell cycle, intracellular drug accumulation and the expression of mRNA and proteins of MDR1, glutathione S-transferase Pi (GSTπ), MDR-related protein (MRP) and topoisomerase IIα (TopoIIα).

  • It has been considered that the overexpression of MDR1/P-gp is a major mechanism of MDR in tumour cells [ 28].


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