Words similar to mdm
Example sentences for: mdm
How can you use “mdm” in a sentence? Here are some example sentences to help you improve your vocabulary:
Pretreatment of mice with RU 486 caused significant increases in hepatic levels of JunB and mdm2 (Fig 2).
Thus phosphorylation of the p53 protein in response to DNA damage or expression of p14Arf prevents mdm2 binding and p53 protein then accumulates in the cell.
In unstimulated cells, the mdm2 protein binds to the N-terminal transactivation domain of p53 and targets it for ubiquitin-dependent degradation [ 6, 7].
In contrast to its effect on JunB and mdm2 mRNA levels, RU 486 diminished the hepatic expression of c-myc and p53 mRNAs to comparable degrees (Fig 3).
p14 Arfbinds to and sequesters mdm2, allowing free p53 protein to accumulate in the cells [ 8].
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