Words similar to mdm
Example sentences for: mdm
How can you use “mdm” in a sentence? Here are some example sentences to help you improve your vocabulary:
They first tested whether the tumours showed amplification of Mdm2.
mdm2 binding is dependent on the phosphorylation status of serine 20 of p53 [ 15], although phosphorylation of serines 15, 33 and 37 also play a role.
Over-expression of homeodomain-interacting protein kinase 2 (HIPK2), which increases p53 protein expression and/or stability, leads to a downregulation of mdm2 protein, but not mRNA [ 29 ] . Consequently, the RU486-induced increase in mdm2 mRNA expression, coupled with a decrease in that of P53, may also act in tandem to suppress the liver apoptotic capacity (Fig 1B).
Thus phosphorylation of the p53 protein in response to DNA damage or expression of p14Arf prevents mdm2 binding and p53 protein then accumulates in the cell.
Probes for mdm2, JunB, c-myc and β-actin genes were also obtained from Ambion, lnc.