Words similar to mdm

Example sentences for: mdm

How can you use “mdm” in a sentence? Here are some example sentences to help you improve your vocabulary:

The authors studied the expression of two p53-upregulated genes ( Cdkn1a , which encodes p21, and Mdm2 ) and one downregulated gene ( Pcna ) in p53-positive tumours after irradiation and showed responses indicative of normal p53 function.
Some tumours therefore amplify the Mdm2 gene as a means of inactivating p53.
The protein product of the mdm2 oncogene is over-expressed in a considerable number of tumors [ 27 ] . This protein is a pivotal negative regulator of p53 [ 27 ] ; it interacts with the P53 protein masking its transcriptional domain and accelerating its proteasomal degradation [ 21 27 ] . The later process involves the deacetylation and ubiquitylation of the p53 protein by mdm2 [ 28 ] . Inactivation and/or degradation of p53 diminishes the cell ability to undergo apoptosis [ 21 ] . Conversely, p53 may influence mdm2.
In the MDM of multi-spanning transmembrane α helices, isoleucine, methionine and valine are found to have relatively high mutability as hydrophobic residues, and serine and threonine also rank high in mutability as polar residues.
They first tested whether the tumours showed amplification of Mdm2.