Words similar to mdm

Example sentences for: mdm

How can you use “mdm” in a sentence? Here are some example sentences to help you improve your vocabulary:

Thus phosphorylation of the p53 protein in response to DNA damage or expression of p14Arf prevents mdm2 binding and p53 protein then accumulates in the cell.
mdm2 binding is dependent on the phosphorylation status of serine 20 of p53 [ 15], although phosphorylation of serines 15, 33 and 37 also play a role.
The protein product of the mdm2 oncogene is over-expressed in a considerable number of tumors [ 27 ] . This protein is a pivotal negative regulator of p53 [ 27 ] ; it interacts with the P53 protein masking its transcriptional domain and accelerating its proteasomal degradation [ 21 27 ] . The later process involves the deacetylation and ubiquitylation of the p53 protein by mdm2 [ 28 ] . Inactivation and/or degradation of p53 diminishes the cell ability to undergo apoptosis [ 21 ] . Conversely, p53 may influence mdm2.
Probes for mdm2, JunB, c-myc and β-actin genes were also obtained from Ambion, lnc.
These DNA damage-induced phosphorylations of p53 block the binding of mdm2 to the N-terminal of the p53 protein [ 18].