Words similar to mdm

Example sentences for: mdm

How can you use “mdm” in a sentence? Here are some example sentences to help you improve your vocabulary:

Hepatic RNA was extracted and quantified as we reported previously [ 10 ] . RNA was mixed with 32P-labeled c-myc, mdm2, p53, JunB, and β-actin probes, then co-precipitated, purified, and electrophoresed on 5% polyacrylamide gel.
Thus phosphorylation of the p53 protein in response to DNA damage or expression of p14Arf prevents mdm2 binding and p53 protein then accumulates in the cell.
The molecular mechanisms leading to breast malignancies are unclear, but many genetic abnormalities and epigenetic factors have been implicated, including changes affecting known tumor suppressor genes ( p53 , BRCA1, BRCA2 , PTEN/MMAC1/TEP1) and proto-oncogenes (neu/ErbB2/HER2 , ErbB1/EGFR , PRAD-1/cyclin D1 , Mdm2 , and c-myc) [reviewed in ref.
In unstimulated cells, the mdm2 protein binds to the N-terminal transactivation domain of p53 and targets it for ubiquitin-dependent degradation [ 6, 7].
Activation of p53 by DNA damage is also brought about by inhibition of p53-mdm2 interaction.