Example sentences for: mdm

How can you use “mdm” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Pretreatment of mice with RU 486 caused significant increases in hepatic levels of JunB and mdm2 (Fig 2).

  • Thus phosphorylation of the p53 protein in response to DNA damage or expression of p14Arf prevents mdm2 binding and p53 protein then accumulates in the cell.

  • In unstimulated cells, the mdm2 protein binds to the N-terminal transactivation domain of p53 and targets it for ubiquitin-dependent degradation [ 6, 7].

  • In contrast to its effect on JunB and mdm2 mRNA levels, RU 486 diminished the hepatic expression of c-myc and p53 mRNAs to comparable degrees (Fig 3).

  • p14 Arfbinds to and sequesters mdm2, allowing free p53 protein to accumulate in the cells [ 8].


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