Words similar to mcl-
Example sentences for: mcl-
How can you use “mcl-” in a sentence? Here are some example sentences to help you improve your vocabulary:
Although expression of Mcl-1 in the neutrophils declined with time, significant amounts were still detectable 48 hours after endotoxin administration.
NF-κB, CREB and C/EBP are transcription factors known to be important in regulating the expression of various genes controlling apoptosis and inflammatory mediator production including Mcl-1, COX-2 and TNF-α [ 20 21 ] , and these were next examined.
Mcl-1 is an anti-apoptotic member of the Bcl-2 family whose expression is correlated with decreased apoptosis and increased survival in human neutrophils [ 15 16 ] . Western blot analysis showed that neutrophils from control animals did not express Mcl-1 protein (Fig.
These findings indicate that prolonged neutrophil survival in the lung vasculature following endotoxin administration may be mediated, at least in part, by Mcl-1.
The proteins were transferred to nitrocellulose paper, and incubated at room temperature for 3 hours, or overnight, at 4°C, with mouse monoclonal anti-human Mcl-1 (1:1000), p38 MAP kinase, phosphoinositide 3 kinase (PI3K), or protein kinase B-alpha (PKB-α) (1:500) antibodies (Transduction Laboratories, San Diego, CA, USA and New England Biolabs, Inc., Beverly, MA, USA), or rabbit polyclonal anti-rat p44/42 MAP kinase (1:1000), or doubly phosphorylated anti-human Thr180/Tyr182 phospho-p38 MAP kinase (1:1000) antibodies (New England Biolabs, Inc.).
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