Example sentences for: mcl-

How can you use “mcl-” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Acute endotoxemia caused a marked induction of Mcl-1 in freshly isolated adherent vascular lung neutrophils, which peaked between 2 and 12 hours and remained elevated for at least 48 hours.

  • NF-κB, CREB and C/EBP are transcription factors known to be important in regulating the expression of various genes controlling apoptosis and inflammatory mediator production including Mcl-1, COX-2 and TNF-α [ 20 21 ] , and these were next examined.

  • Treatment of rats with endotoxin resulted in a rapid induction of Mcl-1, which peaked between 2 and 12 hours.

  • This is consistent with the relatively high levels of apoptosis observed in these cells and their reduced survival in culture [ 29 ] . Our findings are in accord with a recent study demonstrating that Mcl-1 expression in human peripheral blood neutrophils decreases with aging [ 15 ] . As previously reported for human peripheral blood neutrophils [ 30 ] , we were unable to detect Bcl-2 in rat adherent vascular lung neutrophils, even after endotoxin treatment of animals.

  • In contrast to cells from endotoxin treated animals, adherent vascular neutrophils from control animals did not express Mcl-1 protein.


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