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Example sentences for: mbd

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MeCP2's functional structure consists of an 84 amino acid methyl-binding domain (MBD) [ 11 ] and a 104 amino acid transcriptional repression domain (TRD) [ 12 ] . The MBD is able to bind to 5-methyl cytosine residues of a single CpG dinucleotide [ 11 ] . Under the current model, MeCP2 binds to DNA, then complexes with Sin3A through the TRD and recruits histone deacetylases (HDAC).
Clonal mutant and wild-type MECP2 expressing fibroblast cell strains were successfully established from four Rett females with different mutations, one missense in the MBD, one missense in the TRD and two frameshift mutations leading to premature stop codons.
First, redundancy in methyl-CpG binding proteins that recruit transcriptional silencing complexes may mask the effects of MeCP2 deficiency; for example, MBD1, MBD2 or Kaiso, may complement the defect in the cell types we studied.
Alternatively, while MeCP2's expression is ubiquitous, other methyl-CpG binding proteins that exist within complexes, MBD1 and MBD2 [ 19 ] or Kaiso [ 20 ] , may reduce the effect of mutations in MECP2 in peripheral organ systems while the lack of such redundancy may lead to a more pronounced phenotype in the brain.