Example sentences for: maturation

How can you use “maturation” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • These results point to a role of Hoxc-8 in regulation of cartilage maturation and chondrocyte differentiation.

  • Once a mature thymic environment is formed, many, if not all stages of thymocyte maturation require interactions with thymic epithelial cells.

  • On murine T cells and thymocytes, CD81 costimulates T cell receptor-mediated activation, through a pathway independent of CD28 [ 16 ] . On human T cells, CD81 costimulation results in increased IL-2 production and LFA-1-mediated T-B cell adhesion [ 17 ] . Murine CD81 also appears to play a role in thymocyte maturation as shown in fetal thymic organ cultures [ 18 ] .

  • A number of reports have characterized constitutive expression of HSP70 and HSP90 in both immature oocytes and ovulated eggs from various species [ 32 33 34 35 36 ] . HSP70 and HSP89 are constitutively synthesized in the immature, preovulatory mouse oocyte, although the expression is not heat-inducible [ 37 ] . Levels of HSP70 mRNA decrease following oocyte maturation and ovulation [ 38 ] , and HSP70 is one of the first genes to be transcribed at the onset of zygotic gene activation in the early 2-cell mouse embryo [ 39 40 ] . Interestingly, while previous investigators did not localize HSP70 to the oolemma, they did demonstrate that the presence of anti-HSP70 antibody reduces bovine sperm-egg binding in vitro.

  • This localization is quite different from that reported for ejaculated human sperm where SPAM1 is found uniformly over the entire head surface [ 39 ] . Our finding suggests that SPAM1 undergoes redistribution on the sperm head during epididymal maturation in primates as it does in guinea pigs and mice [ 40 10 ] , albeit with a reverse order going from a regionalized to uniform pattern.


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