Words similar to maturation
Example sentences for: maturation
How can you use “maturation” in a sentence? Here are some example sentences to help you improve your vocabulary:
TGF-β expression is closely associated with an increase in wall shear stress [ 30 31 ] and with different forms of fluid shear stress [ 32 ] , and its function is modulated by variety of factors [ 14 ] . For example, TGF-β1 is secreted in an inactive precursor and requires furin-mediated maturation [ 33 ] . TGF-β1 in turn induces expression of furin.
During this transition, tightly-regulated post-translational phosphorylation-dephosphorylation events and proteasome-mediated proteolytic reactions regulate the activation and inactivation of signal transduction pathways that control chromatin condensation, nuclear membrane dissolution, microtubule nucleation, and formation of a haploid oocyte [ 8 9 10 ] . Several kinases that exert major roles during OM include maturation promoting factor (MPF) [ 9 11 ] , mitogen-activated protein kinases (MAPKs) [ 12 13 ] , and the product of the c-mos protooncogene Mos kinase [ 14 15 ] . Also, during OM oocytes undergo two highly-regulated metaphase-anaphase transitions (MAT) in which homologous chromosomes are equally and randomly segregated to an oocyte and first polar body and a subsequent division in which equational division of sister chromatids results in a haploid oocyte and a second polar body.
For instance, changes in expression of CD5, TCR, Bcl-2, RAG and TdT genes can be induced by in vitro TCR engagement of DP thymocytes, thus indicating that at least some aspects in the T cell maturation program are directly coupled to TCR signaling.
However, we observed profilin-dependence of viral maturation even in sub-confluent monolayers where the cells were well separated, as well as in single-burst experiments (data not shown).
This finding was unexpected in light of the severe cartilage defects in Hoxc-8 transgenic mice [ 1 ] . However, the possibility remained that, despite apparently normal maturation, proliferation of chondrocytes could be affected by the Hoxc-8 overexpression.
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