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Example sentences for: matthys
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Matthys et al . recently showed that the enhanced severity of CIA in IFN-γ receptor-deficient mice immunized with type II collagen in CFA is due to an expansion of the CD11b +cells [ 36 ] . Since IL-10 -/-mice produce reduced levels of IFN-γ, we were interested in determining whether there was a specific expansion of CD11b +cells.
Recent work by Matthys et al . demonstrates that the protective effect of IFN-γ is dependent on the presence of the mycobacterial component of the adjuvant [ 36 ] . Only when mice are immunized with collagen in CFA is there an increase in disease severity in IFN-γ receptor-deficient mice.