Words similar to markedly
Example sentences for: markedly
How can you use “markedly” in a sentence? Here are some example sentences to help you improve your vocabulary:
The protective mechanisms recommended by McKinney are opaque to the public and reflect a “business as usual” image that fails fully to account for the markedly changed circumstances and perceptions of academic biomedical research.
The following results of this study suggest that HIV-1 expression leads to cyclin D 1 -mediated G 1 → S progression in infected podocytes: cyclin D 1 transcript and protein levels are markedly up-regulated, phospho-Rb (Ser780) levels are increased, cyclin D 1 protein and phospho-Rb (Ser780) levels do not decrease with podocyte cell-cell contact and differentiation, and the up-regulation of cyclin D 1 requires the expression of HIV-1 genes, particularly HIV-1 nef.
The ability of the CHO-MK cells to incorporate thymidine in response to IGF-I is markedly diminished as compared to the parental cell line (Figure 1B).
Organisms with extreme genome compositions, or with genome compositions that differ markedly from their close relatives (such as Mycoplasma pneumoniae versus other mycoplasmas) should be particularly accessible.
The first evidence that chemokines are associated with wound healing in vivo was reported in 1990 using the chemokine cCAF (chicken Chemotactic and Angiogenic Factor; the product of the 9E3 gene), a CXC chemokine that is now known to be the ortologue for human IL-8 [ 9 ] . cCAF is expressed to high levels very shortly after wounding and during the first 24-48 hours after injury, and remains elevated for at least 16 days after wounding [ 6 10 ] . It is primarily expressed by the fibroblasts of the granulation tissue, especially where interstitial collagen (Coll) is abundant, but the levels are also high in the endothelial cells of the microvessels, in the healing epidermis and in the connective tissue beneath the skin [ 6 11 ] . In the chicken chorioallantoic membrane (CAM) assay, low concentration of cCAF results in chemotaxis of monocyte/macrophages and lymphocytes and the formation of a granulation-like tissue beneath the chemokine-containing pellet [ 3 ] . After four days of exposure to this chemokine, the ectoderm of the CAMs becomes thickened and the amount of fibrillar collagen in the tissue is markedly increased, strongly suggesting that cCAF is able to initiate some of the primary events that lead to granulation tissue formation [ 3 ] .
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