Words similar to markedly
Example sentences for: markedly
How can you use “markedly” in a sentence? Here are some example sentences to help you improve your vocabulary:
In that study, the values for MHCs I, IIa, and IIx were not markedly different from those reported here for normal rat diaphragm by RT-PCR.
The rate of neutropenic events was markedly higher among the validation patients than in patients in the Silber study (84% versus 47%).
In addition to examining the distribution of t statistics, we used this plot to observe points that deviate markedly from the bulk of the observations since they may represent difference in means of the patient and control groups.
M6P/IGF2R is normally imprinted in mice with only the maternal copy of the gene being expressed [ 41 ] . In contrast, both copies of the M6P/IGF2R are expressed in humans because genomic imprinting at this locus was lost in the primate lineage approximately 75 million years ago [ 42 ] . Importantly, restoration of biallelic M6P/IGF2R expression in mice results in a marked reduction in offspring weight late in embryonic development that persists into adulthood [ 43 ] . This demonstrates that M6P/IGF2R allelic loss or haploid insufficiency markedly enhances cell proliferation and/or survival during fetal development.
A role for BMP-5 in dorsal forebrain patterning has been proposed based on its expression in the dorsal midline of the developing forebrain and observations that ectopic expression of BMP-5 in the developing neural tube of chicks markedly downregulates ventral markers while maintaining dorsal markers [ 5 7 ] . Further support for BMP-5 regulation of early forebrain development has been provided by studies of Bmp5/Bmp7 double mutants [ 6 ] . However, reports that BMP-5 in the mouse brain exhibits peak expression levels in the adult striatum and brainstem and that maximal expression in the hippocampus and cerebellum occurs at E18 through PN1 and again in the mature nervous system [ 3 ] , suggest additional roles for BMP-5 during later stages of neural development and into adulthood.
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