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Example sentences for: maritima
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The aroQ•pheA fusion also exists in Thermotoga maritima and Clostridium difficile, apparently having arisen as independent fusion events (G.X.
The single archaeal fusion, the Arachaeoglobus fulgidus protein AF0227, belongs to one of these clusters and shows a strongly supported affinity with the ortholog from the hyperthermophilic bacterium Thermotoga maritima . (Figure 4a,4b).
Specifically, it has been noticed previously that T. maritima shares a considerable number of genes and operons with Gram-positive bacteria, to the exclusion of other bacteria [ 21 ] ; this seems to be compatible with the position of T. maritima with the Gram-positive cluster.
It has been suggested that the mechanisms of these two enzymes may be different [ 33 ] . Direct interaction between the enzyme and the passing strand may not be necessary for the T. maritima topoisomerase I activity.
The relaxation and decatenation activities of T. maritima topoisomerase I appear to be significantly more efficient than those of the E. coli topoisomerase I [ 33 ] . Based on their primary sequences, a number of bacterial topoisomerase I enzymes do not appear to coordinate any Zn(II) with tetracysteines motifs while other type IA topoisomerase has up to 4 tetracysteine motifs [ 7 ] . The topoisomerase I from Mycobacterium smegmatis has been demonstrated biochemically not to bind Zn(II) [ 34 ] . In contrast, mutation disrupting the fourth Zn(II) motif of Helicobacter pylori topoisomerase I abolished enzyme function in vivo [ 35 ] . Therefore there may be significant differences in the mechanisms of type IA topoisomerases from different organisms with respect to requirement of Zn(II) binding for relaxation activity.
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