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Example sentences for: mapleson

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However, PKQuest does incorporate a number of features that are not present in Mapleson's model, including tissue metabolism, capillary limitation (either in the lung or tissue) and ventilation-perfusion mismatch.
Mapleson and colleagues developed a detailed anesthetic PBPK [ 7 8 9 ] and measured the relevant PBPK parameters [ 10 11 12 ] . Smith and colleagues [ 13 14 ] and Fukui and Smith [ 15 16 ] have developed complex PBPKs in which the anesthetic interacts with and modifies the organ parameters.
The only detailed attempts to fit human data with a PBPK are for nitrous oxide in man [ 17 ] and halothane in infants [ 18 ] . Allott, Steward and Mapleson [ 19 ] also fit a PBPK to the experimental data for halothane in the dog.
In contrast to the PBPK model of Mapleson [ 7 ] , PKQuest does not model the vascular time delays and therefore is not applicable to short time kinetics (less than a minute).