Example sentences for: mannose

How can you use “mannose” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • CIS, carcinoma in situ ; HCC, hepatocellular carcinoma; IGF2, insulin-like growth factor 2; LOH, loss of heterozygosity; M6P/IGF2R, mannose 6-phosphate/insulin-like growth factor 2 receptor; PCR, polymerase chain reaction; SNP, single nucleotide polymorphism; TGFβ, transforming growth factor beta; UTR, untranslated region.

  • 4 mM) concentrations of mannose also leads to a significant reduction in 20:1 breakdown.

  • P. carinii attachment to type I pneumocytes may also be mediated by laminin, vitronectin [ 2, 3], or mannose [ 4].

  • The mannose 6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) maps to chromosome location 6q25-27 [ 14 ] ; a chromosomal region predicted to contain a head and neck tumor suppressor gene [ 10 11 ] . It encodes for a receptor that functions in intracellular lysosomal enzyme trafficking, transforming growth factor beta activation, and IGF2 degradation (reviewed in [ 15 16 ] ). Granzyme B internalization by the M6P/IGF2R is also required for cytotoxic T cells to induce apoptosis in cells targeted for death, resulting in this receptor being referred to as a "death receptor" [ 17 ] . Elevated IGF2 levels during murine development arising from M6P/IGF2R deficiency result in cardiac abnormalities, cleft palate, fetal overgrowth and perinatal lethality [ 15 18 ] . Furthermore, large offspring syndrome frequently observed in cloned animals is associated with epigenetic changes in gene regulation and decreased M6P/IGF2R expression [ 19 ] . Thus, the M6P/IGF2R plays a crucial role in regulating mammalian fetal growth and development.

  • P. carinii organisms are phagocytized when they bind to mannose receptors on the surface of macrophages [ 7].


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