Words similar to mannose
Example sentences for: mannose
How can you use “mannose” in a sentence? Here are some example sentences to help you improve your vocabulary:
Tat has been shown to down-regulate mannose receptor, EDF-1, CD3-gamma, and TCR/CD3 surface receptor [ 14 ] . Tat reduces mannose receptor levels and promoter activity in mature macrophages and dendritic cells by interfering with the host transcriptional machinery; resulting in decreased levels of surface mannose receptor needed for Ag (mannosylated albumin uptake) or pathogen capture (Pneumocystis carinii phagocytosis), and eventual delivery to MHC class II-containing intracellular compartments [ 15 ] . EDF-1, a gene down-regulated when endothelial cells are induced to differentiate in vitro , was shown to be down-regulated by Tat at the transcriptional level, resulting in the inhibition of endothelial cell growth and in the transition from a nonpolar cobblestone phenotype to a polar fibroblast-like phenotype [ 16 ] .
P. carinii attachment to type I pneumocytes may also be mediated by laminin, vitronectin [ 2, 3], or mannose [ 4].
The mannose 6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) maps to chromosome location 6q25-27 [ 14 ] ; a chromosomal region predicted to contain a head and neck tumor suppressor gene [ 10 11 ] . It encodes for a receptor that functions in intracellular lysosomal enzyme trafficking, transforming growth factor beta activation, and IGF2 degradation (reviewed in [ 15 16 ] ). Granzyme B internalization by the M6P/IGF2R is also required for cytotoxic T cells to induce apoptosis in cells targeted for death, resulting in this receptor being referred to as a "death receptor" [ 17 ] . Elevated IGF2 levels during murine development arising from M6P/IGF2R deficiency result in cardiac abnormalities, cleft palate, fetal overgrowth and perinatal lethality [ 15 18 ] . Furthermore, large offspring syndrome frequently observed in cloned animals is associated with epigenetic changes in gene regulation and decreased M6P/IGF2R expression [ 19 ] . Thus, the M6P/IGF2R plays a crucial role in regulating mammalian fetal growth and development.
In many organisms, mannose has been shown to be a substrate for hexokinases whereas 3- O -methylglucose is metabolized poorly, if at all, by hexokinases [ 62 65 ] . As a result, processes that are affected by mannose but not by 3- O -methylglucose have been postulated to be regulated via a hexokinase-mediated pathway(s) [ 19 31 32 ] . By this logic, the fact that seed storage lipid breakdown is repressed by the presence of mannose but not by 3- O -methylglucose could also be interpreted to mean that inhibition of seed storage lipid breakdown occurs via a hexokinase-mediated pathway.
Growth on mannose, but not 3-O-methylglucose, leads to reduced rates of seed storage lipid mobilization
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