Words similar to mannose
Example sentences for: mannose
How can you use “mannose” in a sentence? Here are some example sentences to help you improve your vocabulary:
Growth on mannose, but not 3-O-methylglucose, leads to reduced rates of seed storage lipid mobilization
In addition, a recent report indicates that mannose may affect some processes by sequestering phosphate, rather than by stimulating a hexokinase-mediated sugar-response pathway [ 66 ] . Although the mechanism by which mannose acts is uncertain at this time, the fact that it retards lipid breakdown when present at concentrations of only 1.4 mM indicates that the effects of mannose cannot be attributed to osmotic stress.
CIS, carcinoma in situ ; HCC, hepatocellular carcinoma; IGF2, insulin-like growth factor 2; LOH, loss of heterozygosity; M6P/IGF2R, mannose 6-phosphate/insulin-like growth factor 2 receptor; PCR, polymerase chain reaction; SNP, single nucleotide polymorphism; TGFβ, transforming growth factor beta; UTR, untranslated region.
The mannose 6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) maps to chromosome location 6q25-27 [ 14 ] ; a chromosomal region predicted to contain a head and neck tumor suppressor gene [ 10 11 ] . It encodes for a receptor that functions in intracellular lysosomal enzyme trafficking, transforming growth factor beta activation, and IGF2 degradation (reviewed in [ 15 16 ] ). Granzyme B internalization by the M6P/IGF2R is also required for cytotoxic T cells to induce apoptosis in cells targeted for death, resulting in this receptor being referred to as a "death receptor" [ 17 ] . Elevated IGF2 levels during murine development arising from M6P/IGF2R deficiency result in cardiac abnormalities, cleft palate, fetal overgrowth and perinatal lethality [ 15 18 ] . Furthermore, large offspring syndrome frequently observed in cloned animals is associated with epigenetic changes in gene regulation and decreased M6P/IGF2R expression [ 19 ] . Thus, the M6P/IGF2R plays a crucial role in regulating mammalian fetal growth and development.
In many organisms, mannose has been shown to be a substrate for hexokinases whereas 3- O -methylglucose is metabolized poorly, if at all, by hexokinases [ 62 65 ] . As a result, processes that are affected by mannose but not by 3- O -methylglucose have been postulated to be regulated via a hexokinase-mediated pathway(s) [ 19 31 32 ] . By this logic, the fact that seed storage lipid breakdown is repressed by the presence of mannose but not by 3- O -methylglucose could also be interpreted to mean that inhibition of seed storage lipid breakdown occurs via a hexokinase-mediated pathway.
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