Words similar to manner
Example sentences for: manner
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The central point of such analysis is to decompose the original n × p data matrix ( n objects, p variables) in the following manner:
For the bacterial and archaeal species groups, the vast majority of these comparisons were inconclusive because the evolutionary distance between phylogenetic partitions resulted in a saturation of K s . The more closely related human-mouse-rat group did not show saturation of K s . Comparisons of K s and K a for functionally diversified mammalian protein sets did not reveal any cases with K a > K s . This is probably due to the fact that, if directional selection led to the acceleration of the amino-acid substitution rate in these proteins, it acted in an episodic manner [ 6, 7] and on a minority of residues against a constant background of purifying selection [ 8, 9].
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Sections were evaluated in a blinded manner for histologic signs of arthritis and scored as follows: 1, synovial cell proliferation, synovial hypertrophy with villus formation and/or fibrin deposition; 2, inflammation, synovitis and/or generalized inflammation; 3, cartilage disruption, chondrocyte degeneration and/or ruffling of cartilage surface and/or dystrophic cartilage; and 4, joint destruction, cartilage erosion with abundant inflammation and pannus formation with bone erosion.
The CXC chemokines such as IL-8 were originally identified as potent activators and chemoattractants for neutrophils, whereas the CC chemokines such as MCP-1 and RANTES mostly attract monocytes and eosinophils respectively [ 10 ] . Chemokines are secreted in a stimulus-and cell type-specific manner [ 11 12 13 14 15 16 17 ] and are regulated primarily at the level of gene transcription [ 18 19 20 21 22 23 24 ] . The transcriptional promoters of IL-8, RANTES and MCP-1 contain binding sites for the redox-responsive transcription factor NF-κB, which has been shown to be important for their regulation by viral infections and cytokines [ 18 20 23 25 26 27 28 29 30 31 32 33 34 ] .
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