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Example sentences for: manifested
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Indeed, a similar explanation has been invoked to explain the presence of Hsp70 and ubiquitin in nuclear aggregates observed in cells expressing abnormal gene products with poly-Gln tracts, such as huntingtin [ 54 ] and ataxin-1 [ 59 ] . Based on reports that overexpression of chaperones [ 59 62 ] or a dominant-negative form of the ubiquitin-conjugating enzyme [ 63 ] can suppress the formation of poly-Gln protein aggregates, Kaytor and Warren [ 58 ] proposed a three-stage model wherein (i) molecular chaperones initially associate with the misfolded protein, (ii) failure to diminish the pool of misfolded protein leads to aggregation and ubiquitination and (iii) inefficient degradation of the aggregate by the proteasome is manifested by the accumulation of inclusion bodies.
The splitting of laterals could be due to a need for in and fy function during the outgrowth process or to a need for in and fy function at initiation with the consequences only being manifested at a later time.
Mice with transgenes encoding T cell receptors from H-2k-restricted CD4 +and CD8 +T cell clones specific for Tag have been generated [ 28 29 ] . When Rip1-Tag2 was crossed to TCR transgenic mice (TCR1) carrying Tag-specific CD4 +T cells, temporal induction of T cell tolerance to Tag was detected in the pancreatic draining lymph nodes in the double transgenic mice [ 30 ] . The T cell tolerance is manifested in reductions both of idiotypic CD4 +T cell abundance and of the T cell proliferation response to Tag in vitro.
Mefloquine use has been associated with two broad classes of neurological disorders: (i) central and peripheral nervous system disorders including headache, dizziness, vertigo and seizures and (ii) psychiatric events including insomnia, anxiety, affective and major disorders [ 2 ] . It is well known and has been accepted for some time that prolonged disruptions in Ca 2+homeostasis can result in impairment of neuronal function and cell death [ 18 19 ] . Impairment or loss of neurons in specific regions of the brain might be manifested in symptoms reported to have occurred in patients treated with mefloquine.
These changes are qualitatively similar to those reported in severe human emphysema [ 12 13 ] : that is, they too are manifested as a shift toward slower MHC isoforms.
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