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Example sentences for: mancini
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Mancini et al . reported that caspase-2 was localized at the Golgi complex and generated a unique cleavage product of golgin-160 [ 29 ] . Furthermore, these investigators proposed that the Golgi complex transduces proapoptotic signals [ 29 ] . A precedent for this hypothesis was provided by Nakagawa et al ., who reported that caspase-12 is localized to the endoplasmic reticulum and mediates an endoplasmic reticulum-specific apoptosis pathway [ 33 ] . In the present study, we have found that all Golgi autoantigens examined were cleaved in apoptosis in a caspase-dependent manner, as evidenced by studies showing that the pan-caspase inhibitor zVAD-fmk completely blocked the apoptotic fragmentation of these antigens.
It is well established that specific intracellular autoantigens are cleaved into different fragments in Jurkat T cells and other cell types undergoing apoptosis and necrosis [ 20 ] . Mancini et al . reported that golgin-160 (native protein, 160 kDa) was cleaved into a 140 kDa fragment during apoptosis [ 29 ] . We therefore performed an immunoblotting analysis using extracts from Jurkat cells treated with apoptosis-inducing reagent (1 μM STS) or necrosis-inducing reagent (0.
Sequences that once were run together by a studio bent on linearity are now fractured and intercut in accordance with Welles' intentions, and the still-astonishing first shot has been shorn of credits and of the Henry Mancini theme that obscured its cacophonous sound mix.
He could have gone the way of Henry Mancini, a dance-band jazz pianist who realized that there would always be more money in Hollywood.
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