Example sentences for: maltophilia

How can you use “maltophilia” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • This work describes our efforts on metallo-β-lactamase L1 from S. maltophilia.

  • , Burkholderia cepacia , and some strains of Stenotrophomonas maltophilia are usually resistant to colistin [ 8 9 10 11 12 13 14 15 16 17 18 ] . Cross-resistance with other antibiotics has not been reported [ 10 13 ] , and acquired resistance is rare [ 11 17 ] . Although lower susceptibility rates for P. aeruginosa have been reported in patients with cystic fibrosis undergoing chronic prophylactic treatment with inhaled colistin [ 18 ] , 81% of strains of P. aeruginosa from such patients are still susceptible to colistin [ 14 ] .

  • However, because errors are observed mainly for S. maltophilia and much less often for Acinetobacter spp.

  • To combat these enzymes, β-lactamase inhibitors such as clavulanic acid, sulbactam, and tazobactam have been given in combination with a β-lactam containing antibiotic to treat bacterial infections [ 52 ] . One class of β-lactamases that are particularly unaffected by the known β-lactamase inhibitors and have been shown to hydrolyze almost all known β-lactam containing antibiotics including late generation carbapenems at high rates are the metallo-β-lactamases [ 14 15 16 17 18 19 ] . Although there are no reports of metallo-β-lactamases isolated from major pathogens [ 51 53 ] , these enzymes are produced by pathogens such as B. fragilis, S. maltophilia, and P. aeruginosa.

  • S. maltophilia is an important pathogen in nosocomial infections of immunocompromised patients suffering from cancer, cystic fibrosis, drug addition, AIDS and in patients with organ transplants and on dialysis [ 30 31 32 ] . This organism is inherently resistant to most antibiotics due to its low outer membrane permeability [ 33 ] and to β-lactam containing antibiotics due to the production of a chromosomally expressed group 2e β-lactamase (L2) and a group 3c β-lactamase (L1) [ 34 35 ] . L1 has been cloned, over-expressed, and partially characterized by kinetic and crystallographic studies [ 36 37 ] . The enzyme exists as a homotetramer of ca. 118 kDa in solution and in the crystalline state.


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