Words similar to malawian
Example sentences for: malawian
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Interestingly, the TNF-863 SNP, of relatively high frequency in Malawi, shows no evidence of recombination with any other SNPs in the Malawian sample.
In African populations, three TNF promoter SNPs have been independently associated with severe malaria [ 1 2 3 ] . To better understand these complex genetic associations with malaria, we have defined the haplotypic structure of the TNF gene region using 12 SNPs genotyped in 212 Gambian and 84 Malawian adults.
To account for 95% of the haplotypic diversity of TNF , one must genotype 8 of 12 SNPs in The Gambian sample (in order of decreasing informativeness): -3025, -308, 851, -1031, -857, 467, -244, -238; and type 7 SNPs in the Malawian sample: -3025, -1031, 851, -308, 1304, -244, -1073.
The haplotype bearing the TNF-857T allele was not found in Malawi (this site is not polymorphic in the Malawian sample), whereas it has a frequency of 5.2% in The Gambia.
An exact test of population differentiation finds the observed haplotype distributions to be a poor fit of a model of random mating between the Gambian and Malawian samples, with a probability less than 10 -5.