Words similar to major

Example sentences for: major

How can you use “major” in a sentence? Here are some example sentences to help you improve your vocabulary:

The Peking Man Caves and Museum at Zhoukoudian are still a major Beijing tourist site, although many of the important fossils are in collections outside China.
The hardware and equipment to support wet FGD technology involves five major systems.
Exhibitions at the major galleries also promote the work of up and coming younger artists as well as established names.
Results were largely consistent with our hypothesis, but with one major exception: the persistently low Hawaiian colorectal cancer survival in cohort 3. This unpredicted finding led to post hoc analyses that were identical to the previous Cox regression models, but included the available treatment variables (surgery, chemotherapy, radiation, and hormone therapy) as additional predictors.
The NR family contains two related ERs (ERα and ERβ) that conform to the typical three domain NR structure and share extensive sequence homology in the DBD and LBD region [ 20 21 ] . Analysis of the function of the individual ERs in mouse knockout models suggests that the major proliferative effects of estrogen are mediated by ERα and not by ERβ, which seems to play an inhibitory role in proliferation in some studies [ 22 23 ] . The ligand-binding properties of the ERs are different, with ERβ often exhibiting stronger binding to plant-derived phytoestrogens [ 24 ] . More importantly, the ERs exhibit isoform-specific effects on gene expression.