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Example sentences for: mainly
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The enzyme exhibits a high constitutive activity in vitro, but it too can be activated by ARF (reviewed in [ 7 ] ), and by phorbol esters, in intact cells [ 6 9 ] . Several reports have suggested that PLD2 is mainly localized to the plasma membrane [ 6 10 ] , possibly in lipid rafts and caveolar membrane microdomains [ 11 12 ] . Most studies on the physiological functions of PLDs have focused on the product PA, a second messenger involved in mitosis, cellular morphological changes and vesicular trafficking (reviewed in [ 7 13 ] ). However, the downstream events that occur as a consequence of PLD-generated PA production, and the identity of target proteins that are directly regulated by PA remains to be determined.
Turning to the Introduction, written by Betty Kirkpatrick, we read, “There is a school of thought prevalent mainly among older people which seeks to impose a kind of restriction on language that is not imposed on other areas of life.”
Critics find this memoir by the late editor of French Elle extremely poignant--but mainly because of its method of composition.
PEDF binding to cell-surface receptors was assayed using biologically active radioligand 125I-PEDF and Y-79 cells [ 18 ] by a widely-used method with a mechanism of retention of receptors on polyethylenimine-treated glass-fiber filters based mainly on ionic interactions [ 32 ] . Polyethylenimine binds strongly to glass, which is negatively charged and integral membrane proteins tend to be acidic.
On the whole, despite the preliminary screening that callers are subjected to, mainly in order to eliminate cranks, drunks, and undesirables, those who do get through rarely have anything of moment to contribute, the presenters are notably unsympathetic in eliciting a fair exposure of their comments, and the listener is (too) often left with the feeling that the presenter has been too dismissive.
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