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Example sentences for: ltg
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Genes from each class, that is, native genes, potentially transferred genes (LTG), IS and phages, of the four groups of bacterial genomes ( Escherichia , Salmonella , Helicobacter , and Streptococcus ) were then retained for codon-usage analysis when their lengths were greater than 150 base-pairs (bp) to avoid artifacts linked to stochastic variations that might happen in shorter genes.
Therefore, attempts to use codon usage of an LTG as an indication of their phylogenetic origin should be considered with caution.
451; r 2= 0.553), suggesting that the base composition of nonsynonymous sites in LTG is mainly the result of mutational pressures, and hence that their amino-acid composition is exceptionally affected by the constraints acting on the nucleotide sequence.
For example, the KRC/ZAS-C consensus sequence "ATTTTGTGG" matches completely with 6 nucleotides of the RSS nonamer and 3 flanking nucleotides of the human IgH D1, D2, D3 and D4 gene segments [ 35 ] . Furthermore, the MAST search identified KRC-selected motifs near two chromosomal breakpoints: between a t(11:14) translocation of the Ig DH2-2 gene segment and the B cell lymphoma 1 ( BCL-1 ) gene in a mantle cell lymphoma [ 36 ] , and at a t(11:19) translocation of the myeloid lymphoid leukemia ( MLL ) gene and the ENL/MLLT1/LTG19 gene in a T-cell acute lymphoblastic leukemia [ 37 ] . The other hits were derived from loci of cellular genes, pseduogenes, or DNA fragments [ 41 42 43 44 ] . The expression of those genes has not been shown to be regulated by KRC or other family members, therefore, the biological significance of those MAST results is unknown.
In particular, the amino-acid composition of LTG appears to be anomalously determined by base composition, even in comparison to genes of organisms having extreme A+T bias.
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