Words similar to ltbp
Example sentences for: ltbp
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All three TGF-β isoforms and the LTBP (part of the naturally occurring latent TGF-β complex) showed broadly similar immunostaining patterns in the mammary glands of untreated rats at 15 weeks of age (Fig.
Staining was shown to be specific in control experiments in which either the primary antibody was preincubated with a 50-fold molar excess of immunizing peptide before being applied to the section (anti-TGF-β 2 , anti-TGF-β 3 ), or the section was stained with an equivalent concentration of nonimmune rabbit immunoglobulin (anti-TGF-β 1 -LC, anti-TGF-β 1 -CC, and anti-LTBP).
This hypothesis is not only based on analysis of Case 1 reported here but on a similar analysis of five previously reported cases, one with exon 51 skipping [ 19 ] and four with cysteine substitutions immediately N-terminal of the LTBP like domains [ 9 ] . It is also possible, however, that proteolytic fragments of the mutant protein associate with the normal length fibrillin molecules and inhibit their secretion.
None of the chemopreventive agents used, alone or in combination, were found to affect expression of any of the TGF-β isoforms or the LTBP in either ductal epithelium or periductal stroma after 6 weeks of chemopreventive intervention (Fig.
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