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Example sentences for: ls

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It is well established that, besides the MHCII molecules, IFNg can induce susceptible tumors to upregulate the expression of MHC class I antigens [ 43 ] , tumor associated antigens [ 44 ] , costimulatory molecules [ 45 ] , and heat shock proteins [ 46 ] . In addition, IFNg may have antimetabolic and antiproliferative influence on certain types of tumor cells [ 47 ] . It has also been suggested that IFNg may cause responding tumor cells to secrete angiogenesis inhibitors [ 48 ] . As it is not known which of those IFNg effects are missing or restored by PMA in LS1034 cells, a thorough evaluation of the possible clinical implications of our in vitro findings is quite difficult.
Therefore, we conclude that it is unlikely that PMA action in LS1034 carcinoma is mediated through increased synthesis of IFNg receptors.
[ 36 ] ). It has been shown that treatment of cells with phorbol esters leads to accumulation of phosphorylated H3 histones [ 37 ] . Therefore, it seems possible that in LS1034 cells PMA could enhance transcriptional activity of chromatin at promoters of MHCII and/or CIITA genes.
We also found that the effect of PMA in LS1034 cells can be significantly augmented by co-incubation with 172 mM ethanol.
The results demonstrated a substantial increase in MHCII expression in LS1034 cell line following combined incubation with PMA and IFNg (Figure 2).