Words similar to loss-of-function

Example sentences for: loss-of-function

How can you use “loss-of-function” in a sentence? Here are some example sentences to help you improve your vocabulary:

Genetic alterations such as amplification, deletion, translocation and rearrangement could result in either gain-of-function or loss-of-function mutations in genes that modulate aspects of cell proliferation, differentiation, motility and survival.
Equally important, other studies have shown that loss-of-function and naturally occurring mutations in BMP ligands and receptors are associated with dysregulation of folliculogenesis and ovulation [ 14 15 16 17 18 19 ] . Of particular interest is the finding that ewes having a mutation in the bmp15 gene in both alleles are infertile whereas the heterozygotes are superfertile [ 16 ] . Thus, the bmp15 gene can control ovulation quota through a dosage-sensitive mechanism.
Furthermore, if ASW were simply a loss-of-function allele, given the paucity of genes on the W chromosome, sex-chromosome theory [ 4] suggests that such a gene would be lost.
A functional link between the expression of BMPR-IB and luteolysis comes from loss-of-function studies showing that the CL of the cycle continues to secrete progesterone in the absence of BMPR-IB [ 31 ] . This work, together with our finding that BMPR-IB is selectively expressed in the TE of the CL at luteolysis, supports the novel hypothesis that the regulation of inducible and TE specific BMPR-IB gene expression may control luteolysis.
They also showed that only about 40% of the genes had similar loss-of-function phenotypes in both cell lines.