Words similar to loss-of-function

Example sentences for: loss-of-function

How can you use “loss-of-function” in a sentence? Here are some example sentences to help you improve your vocabulary:

Equally important, other studies have shown that loss-of-function and naturally occurring mutations in BMP ligands and receptors are associated with dysregulation of folliculogenesis and ovulation [ 14 15 16 17 18 19 ] . Of particular interest is the finding that ewes having a mutation in the bmp15 gene in both alleles are infertile whereas the heterozygotes are superfertile [ 16 ] . Thus, the bmp15 gene can control ovulation quota through a dosage-sensitive mechanism.
Genetic alterations such as amplification, deletion, translocation and rearrangement could result in either gain-of-function or loss-of-function mutations in genes that modulate aspects of cell proliferation, differentiation, motility and survival.
Prior reports of sex differences in COMT expression in humans [ 77 ] as well as effects of gender on behavior in COMT loss-of-function mouse models [ 78 ] and reports of preferential transmission of the low activity Methionine alleles in females with OCD [ 79 ] suggested that gender could interact with ANT performance.
They also showed that only about 40% of the genes had similar loss-of-function phenotypes in both cell lines.
We found that E2F loss-of-function mutations were the strongest modifiers as they completely suppressed the phenotype.