Words similar to loss-of-function

Example sentences for: loss-of-function

How can you use “loss-of-function” in a sentence? Here are some example sentences to help you improve your vocabulary:

Recently, loss-of-function mutations in another putative membrane transporter, Indy , have been found to increase life span [ 15].
They also showed that only about 40% of the genes had similar loss-of-function phenotypes in both cell lines.
The M6P/IGF2R is also mechanistically involved in the genesis of human cancer [ 6 20 21 22 23 24 ] . M6P/IGF2R loss of heterozygosity coupled with intragenic loss-of-function mutations in the remaining allele is a common event in human cancers [ 6 20 21 22 ] . Inheritance of a tandem repeat polymorphism in the 3' UTR of M6P/IGF2R furthermore predicts for enhanced susceptibility to oral cancer [ 25 ] . Moreover, tumor cell growth is inhibited when M6P/IGF2R expression is restored to normal while it is increased when gene expression is reduced [ 26 27 28 29 ] . The results of these mutational and functional studies clearly demonstrate that the M6P/IGF2R possesses the characteristics necessary to be classified as a tumor suppressor gene [ 30 ] .
We found that E2F loss-of-function mutations were the strongest modifiers as they completely suppressed the phenotype.
Most genetic screens for life-span regulators in Drosophila and other organisms, such as C. elegans , have involved loss-of-function mutations and therefore have identified negative regulators of life span [ 14, 15, 42, 43].