Example sentences for: longstanding

How can you use “longstanding” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • It is intriguing that CD36 expression was not detected in PTECs in diabetic mice with longstanding hyperglycemia in vivo, although underlying mechanisms for the species-dependent differential regulation of CD36 in PTECs in vivo and in vitro between mouse and human remain unclear at this time.

  • One would also have to forgive the Indian subcontinent's most highly trained cardiologist for failing to recognize that It's me dickey ticker, doctor--which sounds as if the patient requires the services of a watch-repairer--is an allusion to longstanding heart disease.

  • Moreover, it is possible that β-cells from patients with longstanding diabetes have a higher threshold for an apoptotic response to DNA-damage than β-cells in normal subjects, as it has been shown that this threshold increases with age [ 43 ] . Consequently, β-cells with high levels of DNA damage from younger individuals with a shorter duration of diabetes might be eliminated by apoptosis, while similarly damaged β-cells from older individuals, who are likely to have had diabetes for a longer time may be resistant to apoptosis and so remain.

  • As noted by Doherty and Zinkernagel [ 4 ] , simple dominance for resistance to each of several diseases can create allele-specific overdominance for total fitness, if different alleles confer resistance to different diseases [ 10 31 ] . For these reasons, our results, while relevant to the longstanding debate over the relative importance of various kinds of balancing selection in maintaining MHC diversity [ 32 ] , raise doubts about only one of several lines of evidence for the overdominance hypothesis.

  • DiGenova has longstanding relationships with reporters, dating from his days as U.S. attorney for the District of Columbia.


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