Words similar to loh
Example sentences for: loh
How can you use “loh” in a sentence? Here are some example sentences to help you improve your vocabulary:
We could examine, by studying multistage individually microdissected tumor components from the same specimen, the extent of heterogeneity associated with chromosome 18p LOH (Fig.
One of the hallmarks of cancer includes the accumulation of mutations in key genes, namely DNA repair genes [ 4 ] , tumor suppressor genes [ 5 6 ] , and proto-oncogenes [ 5 6 ] , accompanied by the loss of the wildtype allele, resulting in loss of heterozygosity [LOH, see reviews by [ 7 8 9 ] ]. Pancreatic cancer, which results in the death of approximately 30,000 Americans annually and is the fourth leading cause of cancer mortalities in the United States, exhibits this hallmark [ 10 ] . For example, in pancreatic cancer there is a high incidence of mutations (>50%) in the tumor suppressor genes p16, p53 and DPC4 and approximately 90% of cases coincide with a mutation in the oncogene K- ras 2 [see review by [ 11 ] ]. Furthermore, a significant percentage of tumors harboring a mutated copy of DPC4 or p53 also lose the corresponding wildtype allele, resulting in LOH [see reviews by [ 11 12 ] ].
Realizing that loss on 18p is only one part of the complex genetic profile for breast cancer, we sought to discover whether genetic alteration on this chromosome correlated with LOH in other regions known to undergo allelic deletion in cancer.
Such an understanding is necessary if detection of LOH or other genetic abnormalities will ever allow for consistent and useful identification of preinvasive breast lesions at higher risk of progression.
Chromosome 18p11 LOH in breast cancer progression
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