Words similar to loh
Example sentences for: loh
How can you use “loh” in a sentence? Here are some example sentences to help you improve your vocabulary:
Studying 15 loci in 264 women, Emi et al found that LOH at markers 1p34, 13q12, 17p13.
3 region to which RASSF1A maps undergoes deletions in many solid tumor types, including GCTs [ 9 ] . RASSF1A encodes a splice variant of human RAS effector homologue, which interacts with the XPA protein and functions as a negative regulator of cell growth [ 16 17 ] . RASSF1A has been shown to be inactivated by promoter methylation in a variety of tumor types [ 16 17 18 19 ] . The 17q21 and 17p13 regions, to which BRCA1 and HIC1 map, respectively, also have been characterized by high frequency of LOH in GCT [ 9 ] . The BRCA 1 gene plays critical roles in DNA repair and recombination, cell cycle checkpoint control, and transcription and has been shown to be hypermethylated in breast-ovarian cancer [ 4 ] . The HIC1 gene is also often hypermethylated in many human cancers [ 20 21 22 ] . The DNA repair gene MGMT encodes O(6)-methylguanine-DNA methyltransferase and this enzyme effectively removes DNA adducts formed by alkylating agents [ 23 ] . Epigenetic inactivation of the MGMT gene was reported in a wide variety of cancers [ 24 25 ] . Also, a low frequency of methylation of the APC , RARB , and FHIT genes was detected in NSGCTs.
These markers define a region on chromosome 18p previously shown to undergo LOH in invasive ductal breast carcinomas as well as non-small cell lung carcinomas and glioblastomas [ 1, 2].
Significant LOH on chromosome 18p11.
High-molecular weight DNA from frozen tumor and the corresponding peripheral blood specimens was isolated as previously described [ 14 ] . A panel of 49 sequence tagged repeat polymorphic (STRP) (24 markers mapped to chromosome 2q, nine on 5p, 11 on 6p, and five on 11q) markers, previously analyzed for LOH, was chosen for scoring MSI [ 14 15 16 17 ] . The criterion for analysis and classification of MSI has been described earlier [ 51 52 ] .
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