Words similar to loci
Example sentences for: loci
How can you use “loci” in a sentence? Here are some example sentences to help you improve your vocabulary:
A number of recent genome-wide screens support the genetic hypothesis in human SLE, and have reported, in aggregate, 48 potential susceptibility loci [ 3, 4, 5, 6, 7] (reviewed [ 8]).
With current analysis software, it is possible to map complex traits like CD, where several genetic loci are probably involved and the mode of inheritance is unclear.
For example, the KRC/ZAS-C consensus sequence "ATTTTGTGG" matches completely with 6 nucleotides of the RSS nonamer and 3 flanking nucleotides of the human IgH D1, D2, D3 and D4 gene segments [ 35 ] . Furthermore, the MAST search identified KRC-selected motifs near two chromosomal breakpoints: between a t(11:14) translocation of the Ig DH2-2 gene segment and the B cell lymphoma 1 ( BCL-1 ) gene in a mantle cell lymphoma [ 36 ] , and at a t(11:19) translocation of the myeloid lymphoid leukemia ( MLL ) gene and the ENL/MLLT1/LTG19 gene in a T-cell acute lymphoblastic leukemia [ 37 ] . The other hits were derived from loci of cellular genes, pseduogenes, or DNA fragments [ 41 42 43 44 ] . The expression of those genes has not been shown to be regulated by KRC or other family members, therefore, the biological significance of those MAST results is unknown.
, the two loci are in strong linkage disequilibrium), then selection cannot act on one locus independently of the second locus.
The reason is simply that this approach has only recently become possible with the advent of high throughput SNP genotyping and we are not currently aware of any published studies that have used genomewide association for identification of susceptibility loci of complex traits.
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