Example sentences for: locf

How can you use “locf” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • In LOCF, one imputes every missing visit time-point by carrying the last observation forward until the end of the study.

  • Since PI does less imputation, it is less biased than LOCF because the assumption of stability usually does not hold.

  • BP = blood pressure; HCTZ = hydrochlorothiazide; DBP = diastolic blood pressure; ITT = intent to treat; MCAR = missing completely at random; ICH = International Conference on Harmonization; LOCF last-observation-carried-forward; PMI = proper multiple imputation; MAR = missing at random; PI = partial imputation.

  • Since LOCF requires the strong assumption of stability, the more it imputes the more bias it introduces if the assumption of stability does not hold.

  • Example 3 also used a ranking method after LOCF for a secondary analysis.


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