Words similar to load
Example sentences for: load
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For instance, they are dispensable for DNA damage-dependent activation of the Rad26/Rad3-kinase complex [ 18 ] , but are required for the Rad3-dependent phosphorylation of Chk1 [ 23 ] . Structural predictions of Hus1, Rad1 and Rad9 have led to the proposal that all three fold similarly to the subunits of Proliferating Cell Nuclear Antigen (PCNA) [ 24 25 26 ] . Consistent with these predictions, PCNA exists as a homotrimer [ 27 ] while Hus1, Rad1 and Rad9 all interact and possibly form a heterotrimer [ 25 28 ] . In addition, Rad17 has sequence similarity and physical interactions with subunits of Replication Factor C (RFC) [ 29 30 ] . Based on the RFC-PCNA paradigm, the Rad17-RFC complex may load the PCNA-like Rad9-Rad1-Hus1 (9-1-1) complex onto genomic lesions discovered by the Rad26/Rad3 complex.
After an oral glucose load (Figure 1), the Ff/ff subjects had similar plasma glucose levels at each time point compared to the FF subjects.
Clinical and laboratory parameters (CD4 count and viral load) were monitored at each visit, and venous blood was collected for additional secondary outcomes during selected study visits.
By 72 hr postinfection, the macrophage cytoplasm is dark and the cell appears necrotic, possibly due to the heavy mycobacterial load or apoptosis.
Previous work has suggested that although SERCA expression in limb muscles seems to respond to increases in functional load by upregulating SERCA 2 (the slow SERCA isoform) and downregulating SERCA 1 (the fast isoform) [ 50 ] , similar responses might not occur in diaphragm [ 51 ] . Our data showing no difference in the expression of SERCA 1 and SERCA 2 between emphysematous and control animals are consistent with this finding.