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Example sentences for: lncap

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Figure 5shows that treatment of LNCaP cells with RA (100 nM) alone for 24 h resulted in > 20% decrease in the binding of 125I-EGF and membrane proteins (P < 0.05).
Polyubiquitylation of wildtype, but not mutant p27 was observed in untreated LNCaP cell lysate (Fig.
An association between autocrine IL-6 and PCA has been known for some time [ 16 17 ] . The change in prostate cell phenotype from paracrine IL-6-stimulated to autocrine IL-6-stimulated is believed to be a contributing factor in the progression from benign hyperplasia to neoplasia [ 17 ] . IL-6 is also implicated in the development of cancer cell resistance to chemotherapy in PCA patients [ 18 19 ] . In other studies, a chimeric protein consisting of an anti-IL-6 Ab fused to Pseudomonas exotoxin was found to inhibit proliferation of prostate carcinoma cell lines [ 20 ] . Exogenous IL-6 activated androgen responsive gene expression in the absence of androgens in human LNCaP cells [ 21 ] . More work is needed to clarify the role of IL-6 in prostate neoplasia.
Binding between LNCaP cell nuclear extract and oligo probe of RAR α promoter thus suggests that AR-ARE interaction might mediate the effects of T on the expression of RAR α in LNCaP cells.
When the cells were treated with T in the presence of 100 nM RA, the RAR α and γ mRNAs in LNCaP cells were suppressed in a dose dependent manner (P < 0.05, Figure 3).