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Example sentences for: lncap

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4C), we conclude that SKP2 directly triggers the ubiquitylation and degradation of p27 in LNCaP cells, a process which is attenuated by androgen-mediated SKP2 downregulation.
Similarly, treatment of LNCaP cells with 0.01-10 nM RA alone resulted in 50-70% stimulation of 3H-thymidine uptake (p < 0.05, Figure 1B); these effects were suppressed by concomitant presence of 0.02-200 nM T (p < 0.05).
In this regard, RA was reported to blunt the growth response of LNCaP cells to EGF [ 31 ] . These investigators also reported increases and decreases in LNCaP cells in S-phase after exposure to growth stimulating and anti-proliferative doses of RA, respectively.
Perhaps a more detailed investigation of expression changes within the first 8 hours after treatment will reveal temporal patterns of response of LNCaP to androgens and provide additional insights into androgen action.
In continuing our studies on the role of IL-6 in STAT3 phosphorylation, we used the JAK2 phosphorylation inhibitor AG490, to see if inhibiting JAK2 phosphorylation would inhibit survival of NRP-152 or NRP-154 cells, as had been described for LNCaP cells previously [ 29 ] . We examined clones of NRP-154, selected by amount of IL-6 expression each had: 2 high IL-6-expressing clones and 2 low-IL-6-expressing clones were used for these experiments.