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Example sentences for: lncap
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To determine whether SKP2 downregulation is a necessary step in MIB-induced p27 upregulation, LNCaP cells were blocked with MIB for 72 h, followed by infection with Ad-SKP2 or Ad-SKP2-ΔF for various periods.
We treated LNCaP prostate cancer cells with androgen under similar conditions and readily identified nearly 500 transcripts modulated by androgen with unsupervised hierarchical clustering analysis and with supervised methods ( [ 9 ] and data not shown).
Stimulation of RAR α and γ mRNA in LNCaP cells by T differed from that in normal rat prostate and non-tumorigenic rat prostate epithelial cells (NRP-152), but was comparable to that in tumorigenic rat prostate epithelial cells (NRP-154) [ 13 14 ] . In cervical carcinoma cells, the RAR β gene was abnormally down-regulated by RA [ 36 ] . In ER positive human breast cancer cells, RAR α mRNA was also up-regulated by estrogen [ 16 ] . Thus, T stimulation of RAR mRNAs in LNCaP cells could be related to the pathologic state of the cells.
Treatment with 1 nM R1881 promotes proliferation in the MDA PCa 2a and 2b cell lines, has no proliferative effect in the LNCaP and LAPC-4 cell lines, and represses proliferation in LNCaP cell lines carried for prolonged periods in conditions of androgen deprivation (data not shown, and see references in [ 17, 18, 19]).
Our data suggest that androgen-mediated SKP2 downregulation is responsible for decreased ubiquitylation and accumulation of p27 in LNCaP cells, an effect that is readily overcome by overexpression of SKP2.
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