Words similar to lncap
Example sentences for: lncap
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Regardless of the outcome of such experiments, our data firmly suggest that SKP2 is a central mediator of the androgen response mechanism of LNCaP cells.
The current experiments investigate the effects of T and its interaction with RA on cell growth and the expression of RARs in human prostate cancer cells, LNCaP.
Hierarchical clustering of the expression patterns of 567 transcripts representing 517 unique genes with statistically significant changes in expression in response to 1 nM R1881 in LNCaP is displayed in Figure 1a.
Treatment with 1 nM R1881 promotes proliferation in the MDA PCa 2a and 2b cell lines, has no proliferative effect in the LNCaP and LAPC-4 cell lines, and represses proliferation in LNCaP cell lines carried for prolonged periods in conditions of androgen deprivation (data not shown, and see references in [ 17, 18, 19]).
In three of these cell lines, LNCaP, MDA PCa 2a and MDA PCa 2b, mutations in the ligand-binding domain of the AR confer broad steroid-binding affinity [ 8, 9].