Words similar to lmna

Example sentences for: lmna

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Of note, mice with a null allele in lmna display a phenotype only in the homozygous state [ 22 ] . The mutation we now describe is predicted to generate a substantial protein fragment consisting of the first 37 KDa of lamin A/C.
She is a member of the kindred initially described by Graber et al [ 1 ] . We screened this individual for mutations and found a novel mutation in exon 5 of LMNA . This two bp deletion is predicted to disrupt the reading frame and produce a truncated lamin A and C.
This model was first raised when LMNA mutations were primarily associated with disorders affecting striated muscle [ 24 ] . Interestingly, the preferential involvement of the specialized cells of the cardiac conduction system may support less the stress hypothesis as the cells of the atrioventricular node are less expected to undergo considerable deformation.
However, it is clear that mutations in LMNA cause tissue-specific disease affecting various differentiated cells including cardiac and skeletal muscle, adipocytes and neurons.
PCR primers were designed to amplify all twelve protein coding exons of LMNA (Table I).