Example sentences for: lmna

How can you use “lmna” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The majority of reported LMNA mutations are missense.

  • The exact mechanism by which LMNA mutations cause disease is not clearly elucidated at this time.

  • 2 locus [ 9 ] . Mutations in the LMNA gene associated with DCM have a more severe prognosis and higher-event rates compared to individuals with DCM that do not have LMNA mutations [ 20 ] . A recent report describing another family with a LMNA mutation causing DCM and conduction system disease documents the need for permanent pacemaker implantation [ 21 ] . Previous reports on the proband's kindred support a high-event rate in family members often resulting in sudden cardiac death even in family members with permanent pacemakers [ 10 ] . For example, ten out of 38 family members with pacemakers for high-grade atrioventricular block died suddenly.

  • Subjects with LMNA mutations should be carefully evaluated for both pacemakers and defibrillators.

  • However, it is clear that mutations in LMNA cause tissue-specific disease affecting various differentiated cells including cardiac and skeletal muscle, adipocytes and neurons.


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