Example sentences for: lipoxygenase

How can you use “lipoxygenase” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Capsaicin's use in the treatment of chronic pain is due to an analgesic effect that is explained by capsaicin's action of depletion of stores of substance P from primary sensory neurons as a consequence of the reduced production of prostaglandin [ 39 60 ] . Capsaicin's antiphlogistic activity is due to the "counter-irritant effect"; which means that a local irritant effect exerts an additional more remote antiinflammatory effect [ 60 ] . This is explained by a liberation of corticoids under the influence of certain cutivisceral reflexes [ 60 ] . The counter-irritant effect on the gastric mucosa also occurs because capsaicin stimulates production of the cytoprotective prostaglandin E 2 [ 60 ] . Capsaicin produces analgesic and antiinflammatory effects because it inhibits both 5-lipoxygenase and cycoloxygenase [ 39 ] . A 10 g human ingestion of red pepper stimulated carbohydrate oxidation [ 62 ] . This may explain why the Chocó Indians used it to give their hunting dogs more "energy" [ 25 ] .

  • It has been proposed that vitamin E may incorporate into cellular membranes by association of the tocopherol side chain with the polyenoic fatty acid residues in the membrane fatty acids [ 15 19 ] . This interaction may stabilize cell membranes by making highly unsaturated fatty acids less liable to peroxidation as well as by making highly unsaturated fatty acids less available for phospholipid hydrolysis by phospholipase [ 15 16 ] . The latter action may reduce mobilization of arachidonic acid (AA) from the membranes and in this way reduce the amount of AA available as a substrate to cyclooxygenase and/or lipoxygenase to produce eicosanoids with mitogenic and with inflammatory properties [ 17 20 ] . Other possible antitumor actions include: induction of apoptosis, interference with hormone production, modulation of cellular signaling and gene transcription, and induction of differentiation [ 4 21 22 23 24 ] .


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