Words similar to lipid-lowering
Example sentences for: lipid-lowering
How can you use “lipid-lowering” in a sentence? Here are some example sentences to help you improve your vocabulary:
Unlike, MIRACL and the A-2-Z trials, this study will not assess the efficacy of early statin therapy after an acute coronary syndrome; rather, it will examine the role of more vs. less aggressive lipid-lowering in this setting.
These obvious treatment gaps are disconcerting, especially in light of the recent Adult Treatment Panel III update[16] that supports more intensive lipid-lowering drug therapy for patients at high and moderately high risk for a heart attack.
Friedmann et al used a mail survey to measure 599 physicians' estimates of risk for three CHD risk scenarios, one of which involved lipid-lowering therapy.
Whether lipid-lowering therapy would provide incremental benefit if initiated immediately following an acute coronary syndrome is an important issue as the risk of a recurrent adverse cardiac events is much greater in patients with unstable coronary disease than in the stable setting.
Even if these findings are not confirmed after further study, one could still make a compelling argument that lipid-lowering therapy (barring contraindications) should be initiated early and universally in patients who present with an acute coronary syndrome: First, the long-term safety and effectiveness of statins for the secondary prevention of stable coronary disease is well-established [ 1 2 3 ] ; Second, as evidenced by MIRACL, these agents are safe when initiated at the time of hospitalization for an acute coronary syndrome; Third, the in-hospital initiation of lipid-lowering therapy appears to promote greater long-term utilization of these agents [ 18 19 20 21 ] . Finally, although lipid levels may be unreliable in the setting of an acute coronary syndrome (excepting total :HDL and LDL:HDL cholesterol ratios [ 22 ] ) the overwhelming majority of patients with coronary disease will ultimately require both pharmacologic and non-pharmacologic lipid-lowering interventions to attain recommended cholesterol targets [ 23 24 25 ] ; newer guidelines are even more stringent [ 26 ] . Furthermore, data from the recently presented Heart Protection Study suggest that clinical benefits may accrue independent of baseline cholesterol level [ 4 ] . Thus, to withhold lipid-lowering therapy from patients who present with an acute coronary syndrome would be to accept the status quo, and to date our efforts at cholesterol lowering in the secondary prevention setting have been dismal [ 27 28 ] .
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