Words similar to lipid-lowering
Example sentences for: lipid-lowering
How can you use “lipid-lowering” in a sentence? Here are some example sentences to help you improve your vocabulary:
An open-label lipid-lowering component is designed to determine if lowering LDL cholesterol with pravastatin compared to "usual care" reduces all-cause mortality in a subset of moderately hypercholesterolemic patients.
The accuracy of physicians' estimates of CHD risk after therapy with lipid-lowering drugs was examined by calculating the relative risk reduction (RRR, defined as the baseline risk - risk after therapy, divided by the baseline risk) and comparing it against a value of 30% derived from a meta-analysis of primary prevention trials.
Even if these findings are not confirmed after further study, one could still make a compelling argument that lipid-lowering therapy (barring contraindications) should be initiated early and universally in patients who present with an acute coronary syndrome: First, the long-term safety and effectiveness of statins for the secondary prevention of stable coronary disease is well-established [ 1 2 3 ] ; Second, as evidenced by MIRACL, these agents are safe when initiated at the time of hospitalization for an acute coronary syndrome; Third, the in-hospital initiation of lipid-lowering therapy appears to promote greater long-term utilization of these agents [ 18 19 20 21 ] . Finally, although lipid levels may be unreliable in the setting of an acute coronary syndrome (excepting total :HDL and LDL:HDL cholesterol ratios [ 22 ] ) the overwhelming majority of patients with coronary disease will ultimately require both pharmacologic and non-pharmacologic lipid-lowering interventions to attain recommended cholesterol targets [ 23 24 25 ] ; newer guidelines are even more stringent [ 26 ] . Furthermore, data from the recently presented Heart Protection Study suggest that clinical benefits may accrue independent of baseline cholesterol level [ 4 ] . Thus, to withhold lipid-lowering therapy from patients who present with an acute coronary syndrome would be to accept the status quo, and to date our efforts at cholesterol lowering in the secondary prevention setting have been dismal [ 27 28 ] .
The dominance of statins as lipid-lowering agents grew markedly from 47% of all lipid-lowering medications in 1992 to 87% in 2002 (Figure 1).
In spite of being clearly underused, statins increasingly dominate lipid-lowering drug therapy, accounting for 92% of all lipid-lowering medications used in 2002, which confirms the trends seen in United States retail pharmacy dispensing data [2].
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