Words similar to lethality
Example sentences for: lethality
How can you use “lethality” in a sentence? Here are some example sentences to help you improve your vocabulary:
Acute lethality is an obvious and easily observed effect which accounts for its wide use in the early period of evaluation of the toxicity of pure compounds and complex effluents.
In order to avoid possible in utero lethality caused by excess pathway activity, we used the murine PrP promoter element to construct our transgenic lines.
In contrast, dark-grown seedlings undergo skotomorphogenesis (or etiolation), typified by elongated hypocotols and closed cotyledons [ 1 ] . COP1 was first identified through genetic screens as a negative regulator of light regulated development in Arabidopsis [ 2 ] . Arabidopsis cop1 mutant seedlings are constitutively photomorphogenic even when grown in the dark, and the severe cop1 mutants cause lethality in the late seedling stage, indicating that COP1 is essential for plant development [ 2 3 ] . Arabidopsis COP1 (Arabidopsis thaliana COP1, AtCOP1) is essential for the proteasome-dependent degradation of two transcription factors, HY5 and HYH [ 4 5 ] . These two homologous bZIP-type transcription factors directly interact with AtCOP1 and are capable of binding to light-responsive promoters to activate the transcription of many target genes [ 5 6 ] . Genome wide micro-array analysis shows that AtCOP1 regulates most, if not all, of the light-responsive genes under various light conditions [ 7 8 ] , substantiating the notion that AtCOP1 functions as a crucial developmental switch through targeting key transcription factors for degradation, thereby controlling the light-responsive gene expression and photomorphogenic development.
If these channels are essential elsewhere in the body, as DeSimone suspects, to avoid lethality he will need to construct conditional knockouts in which the channel is lost only in the taste receptor cells.
The functions of Boi1/Boi2 appear to be linked to those of Cdc42 and Rho3, which are Rho-type GTPases that are important for polarized cell growth [ 4 5 6 7 8 9 ] . Boi1 and Boi2 display two-hybrid interactions with both wild-type and mutationally activated Cdc42 but not with a mutant version of Cdc42 that is predicted to be impaired in the ability to bind nucleotide, suggesting that Boi1 and Boi2 may associate with the GTP-bound ("active") form of Cdc42 [ 1 ] . Further evidence that some function of Boi1 is linked to that of Cdc42 is that overexpression of Boi1 inhibits bud emergence and that this inhibition can be suppressed by overexpression of Cdc42 [ 1 2 ] . RHO3 can serve as a multicopy suppressor of the lethality caused by deletion of BOI1 and BOI2 [ 1 2 ] . These findings are consistent with the possibilities that Boi1 and Boi2 are targets of Cdc42 that promote cell growth in a manner that is regulated by Rho3.
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