Words similar to lethality
Example sentences for: lethality
How can you use “lethality” in a sentence? Here are some example sentences to help you improve your vocabulary:
Negative mutations of HSC70 in the nervous system of Drosophila larvae resulted in both developmental defects and lethality [ 31 ] . The increased HSC70 gene expression during trophoblastic elongation is temporally associated with neural tube development in pig conceptuses.
Disruption of gene encoding BTF3 protein in the mouse caused postimplantation lethality around embryonic day 6.5 [ 30 ] . Detailed studies have not been reported in the literature.
The functions of Boi1/Boi2 appear to be linked to those of Cdc42 and Rho3, which are Rho-type GTPases that are important for polarized cell growth [ 4 5 6 7 8 9 ] . Boi1 and Boi2 display two-hybrid interactions with both wild-type and mutationally activated Cdc42 but not with a mutant version of Cdc42 that is predicted to be impaired in the ability to bind nucleotide, suggesting that Boi1 and Boi2 may associate with the GTP-bound ("active") form of Cdc42 [ 1 ] . Further evidence that some function of Boi1 is linked to that of Cdc42 is that overexpression of Boi1 inhibits bud emergence and that this inhibition can be suppressed by overexpression of Cdc42 [ 1 2 ] . RHO3 can serve as a multicopy suppressor of the lethality caused by deletion of BOI1 and BOI2 [ 1 2 ] . These findings are consistent with the possibilities that Boi1 and Boi2 are targets of Cdc42 that promote cell growth in a manner that is regulated by Rho3.
However, expression of alleles that result in embryonic lethality cannot be studied using regular transgenic procedures because lines of founder mice cannot be established.
The fathead minnow, Pimephales promelas, embryo-larval survival and teratogenicity test incorporates teratogenic effects in addition to lethality.
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