Words similar to let-

Example sentences for: let-

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Our observation that the temporal expression profile of miR-100 (Figure 5d) is similar to that described for let-7 and miR-125 (that is, expression is initiated during larval/pupal development and continues through adulthood [ 9 29 ] ) is consistent with probable coordinate expression of all three as a single pri-miRNA transcript, and may further implicate miR-100 in developmental timing.
Although complementary sites for both miRNAs are found in the 3' UTRs of several putative nematode targets, these miRNAs are not physically linked in the C. elegans genome and their mutant phenotypes are principally due to misregulation of different transcripts [ 4 5 6 8 ] . The function of these miRNAs has not yet been explicitly demonstrated in other species, but Drosophila let-7 is regulated at the larval-pupal transition by ecdysone [ 49 ] , and all three members of this cluster are present in other insects and in vertebrates, thus implying broadly conserved functions.
miR-125 is an apparent homolog of C. elegans lin-4 [ 29 ] , which functions with let-7 to regulate developmental timing in nematodes.
Another notable cluster that includes previously identified miRNAs is one containing mir-100 , let-7 and mir-125 (Figure 7c).
This is well illustrated by the Drosophila let-7 orthologs, which have accumulated four mismatches and gaps in the loop sequence but maintain perfectly conserved arms (Figure 2b).