Words similar to let-
Example sentences for: let-
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This is well illustrated by the Drosophila let-7 orthologs, which have accumulated four mismatches and gaps in the loop sequence but maintain perfectly conserved arms (Figure 2b).
The starting point for our studies was a reference set of 24 Drosophila pre-miRNA sequences ( let-7 , the 21 originally identified by Lagos-Quintana and colleagues, mir-125 , and a previously undescribed paralog of mir-2 that we named mir-2c [ 9 10 29 ] ). We analyzed this set to derive rules and determine parameters that specifically describe known miRNA genes within anonymous genomic sequence.
Another notable cluster that includes previously identified miRNAs is one containing mir-100 , let-7 and mir-125 (Figure 7c).
While this work was under review, the clustering of miR-100, let-7 and miR-125 was independently reported; these researchers also provide evidence for coordinate expression of these miRNAs as a single pri-miRNA [ 45 50 ] .
miR-125 is an apparent homolog of C. elegans lin-4 [ 29 ] , which functions with let-7 to regulate developmental timing in nematodes.
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