Words similar to lerisetron
Example sentences for: lerisetron
How can you use “lerisetron” in a sentence? Here are some example sentences to help you improve your vocabulary:
[ 3H]granisetron does not appear to interact with any of the amino acids tested while d -tc interacts with only Y140, m CPBG and 5-HT with Y142 and lerisetron with both Y142 and Y152.
i for analog 2 suggests that analog 2 binds weakly to Y152 while lerisetron and analog 1 bind more tightly.
This is a moderately small change for an alanine mutation, particularly considering that the smallest change in K i for removal of a functional group on lerisetron (the N-benzyl group) was 31 fold.
Identification of amino acids interacting with Lerisetron
While these K i values are significantly different from wildtype values for each analog, the lack of larger effects suggests that neither analog 1 nor analog 2 bind as strongly as lerisetron to Y142.