Words similar to lc-pufa
Example sentences for: lc-pufa
How can you use “lc-pufa” in a sentence? Here are some example sentences to help you improve your vocabulary:
Hepatic gene transcriptional profiles and ontology classifications indicated that fish oil LC-PUFA likely increased FA β-oxidation and gluconeogenesis, and decreased FA synthesis.
These same conclusions regarding energy expenditure were reached in experiments assessing enzymatic activities, and transcriptional changes in rat liver using Northern blots, where fish oil feeding: increased palmitoyl CoA mitochondrial and peroxisomal oxidation rate; increased Cpt1, Cpt2, Δ 3, Δ 2-enoyl CoA isomerase, and Ech1 expression and activity; and decreased expression and activity of FA synthase, malic enzyme, glucose 6-phosphate dehydrogenase, and pyruvate kinase, compared to palm and/or safflower oil feeding [ 93 ] . Likewise, in rat white retroperitoneal adipose tissue, fish oil feeding also decreased Fasn expression [ 94 ] . Intriguingly, the hormone leptin, which also acts through SREBP-1 and PPARα, affected many transcripts similarly to LC-PUFA ( e.g. , leptin decreased Gpam and Apoa4 transcripts; and up regulated Ech1, mitochondrial Hmgcs2, and Cyp4a14 transcripts [ 95 ] .
HNF3γ protein may be involved in etiology of obesity, hyperlipidemia, and diabetes, by regulating glucagon transcription, insulin resistance, and pancreatic γ cell function [ 40 41 ] . To our knowledge, the regulation of hepatic HNF3γ expression by LC-PUFA has not been previously reported.
Only with future studies in which PPAR-specific agonists and antagonists are included, along with receptor antagonists, will the precise role of PPAR-signaling in response to LC-PUFA feeding be elucidated.
Although dietary LC-PUFA activated numerous transcriptional factors in both liver and hippocampus, it is a noteworthy difference that the transcriptional signatures for PPAR, SREBP, and HNF could not be detected in the hippocampal dataset.
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