Words similar to lc-pufa
Example sentences for: lc-pufa
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Studies have yet to resolve all the mechanisms of action of LC-PUFA, in particular the remarkable phenotypic differences between populations that consume different quantities of fish and fish oil in their diets [ 1 2 3 4 5 ] . Dietary LC-PUFA affect processes including: growth, neurological development, lean and fat mass accretion, reproduction, innate and acquired immunity, infectious pathologies of viruses, bacteria and parasites; and the incidence and severity of virtually all chronic and degenerative diseases including cancer, atherosclerosis, stroke, arthritis, diabetes, osteoporosis, and neurodegenerative, inflammatory, and skin diseases [ 6 7 8 9 10 11 ] . Due to lack of mechanistic knowledge, predictions for optimal intake of nutritionally important LC-PUFA remain vague and dietary recommendations simply relate to prevention of overt deficiency.
In the hippocampus, dietary LC-PUFA activated a different set of transcription factors than observed in the liver, including: nuclear factor of κ light chain gene enhancer in B cells 1 p105 (Nfkb1); nescient helix loop helix 1 (Nhlh1); E2F transcription factor 3 (E2f3); basic transcription factor 3 (Btf3); inhibitor of DNA binding 1 (Idb1); D site albumin promoter binding protein (Dbp); paired box gene 9 (Pax9); and the ELK1 member of the ETS oncogene family.
The GO analysis and specific gene expression patterns were interpreted to indicate that LC-PUFA-enriched oils affected liver metabolism through the regulation of genes directly involved in FA metabolism and lipid binding/transport (Figure 2), as previously reported in rats [ 18 ] . When examining GO classifications for the hippocampus, such descriptors as cell signaling and cell cycle control are seen in response to dietary LC-PUFA.
The 5% LFC method indicated that 513 genes in the hippocampus and 489 genes in the liver were differentially regulated by LC-PUFA from the original 13,179 genes represented on the Mu11K Affymetrix GeneChip.
Mice were fed relatively low fat diets to minimize the accretion of body fat and to avoid the confounding effects that LC-PUFA -rich diets are known to exert on the progression of obesity.
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