Words similar to lbd

Example sentences for: lbd

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Consistent with this notion, the apparent weak transcriptional activity of the ERβ LBD is a consequence of corepressor HDAC activity at some level (Fig.
The unliganded LBD recognizes hydrophobic motifs, termed interaction domains (IDs), which are reiterated three times in N-CoR and twice in SMRT and conform to the consensus L/IXXIIXXXL [ 4 ] (see also [ 16 ] ). By contrast, the liganded LBD binds shorter hydrophobic motifs termed NR boxes that are reiterated several times within each coactivator and conform to the consensus LXXLL.
8Bshows that the isolated ERα LBD exhibited more potent transcriptional activity than the ERβ LBD.
Although the poorly conserved NTD region clearly plays an important role in isoform-specificity [ 32 33 ] , it is also likely that there are differences in the better conserved LBD region that contribute to differential ERα and ERβ activities.
Control two-hybrid assays confirmed that a VP16-TRβ LBD fusion protein bound N-CoR in the absence of hormone, but not in the presence of T3.