Words similar to lbd
Example sentences for: lbd
How can you use “lbd” in a sentence? Here are some example sentences to help you improve your vocabulary:
VP16-ERβ LBD and Gal-ERβ LBD contain human ERβ sequences and were gifts from Dr. Dale Leitmann (University of California, San Francisco).
The LBD utilizes a large hydrophobic cleft composed of residues along H3 and H5 to bind IDs [ 17 ] , and a smaller hydrophobic cleft that is composed of residues in the upper part of H3 and H5 and H12 (and corresponds to AF-2) to bind NR boxes [ 18 ] . Thus, agonists promote coregulator exchange by promoting the packing of H12 over the lower part of the ID binding region, an event that simultaneously completes the coactivator binding surface.
To examine interactions between ERβ and N-CoR in mammalian cells we performed two-hybrid assays using a GAL4 DBD/N-CoR C-terminus fusion protein as bait and a VP16-ERβ LBD fusion as the prey.
Consistent with this notion, the apparent weak transcriptional activity of the ERβ LBD is a consequence of corepressor HDAC activity at some level (Fig.
8Bshows that the isolated ERα LBD exhibited more potent transcriptional activity than the ERβ LBD.
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