Words similar to lbd

Example sentences for: lbd

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The following plasmids (pSG5-ERα, pSG5-ERβ (amino acids 1-530) [ 31 ] , pGEX-N-CoR and pGEX-SMRT [ 39 ] , VP16-TRβ and Gal-N-CoR [ 16 ] , GST-N-CoR fusions [ 17 ] , ERE-LUC, GK1/Gal4 responsive reporter and Gal-ERα LBD [ 53 ] , pM-D2, pM-D47, pM-F6 [ 46 ] ) have been previously described.
8Bshows that the isolated ERα LBD exhibited more potent transcriptional activity than the ERβ LBD.
NRs consist of three domains, the N-terminal domain (which contains a context-specific activation function AF-1), the central DNA binding domain (DBD) and the C-terminal ligand binding domain (LBD), which contains a hormone-dependent activation function, AF-2.
The LBD utilizes a large hydrophobic cleft composed of residues along H3 and H5 to bind IDs [ 17 ] , and a smaller hydrophobic cleft that is composed of residues in the upper part of H3 and H5 and H12 (and corresponds to AF-2) to bind NR boxes [ 18 ] . Thus, agonists promote coregulator exchange by promoting the packing of H12 over the lower part of the ID binding region, an event that simultaneously completes the coactivator binding surface.
Control two-hybrid assays confirmed that a VP16-TRβ LBD fusion protein bound N-CoR in the absence of hormone, but not in the presence of T3.