Words similar to lbd

Example sentences for: lbd

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NRs consist of three domains, the N-terminal domain (which contains a context-specific activation function AF-1), the central DNA binding domain (DBD) and the C-terminal ligand binding domain (LBD), which contains a hormone-dependent activation function, AF-2.
The following plasmids (pSG5-ERα, pSG5-ERβ (amino acids 1-530) [ 31 ] , pGEX-N-CoR and pGEX-SMRT [ 39 ] , VP16-TRβ and Gal-N-CoR [ 16 ] , GST-N-CoR fusions [ 17 ] , ERE-LUC, GK1/Gal4 responsive reporter and Gal-ERα LBD [ 53 ] , pM-D2, pM-D47, pM-F6 [ 46 ] ) have been previously described.
8Bshows that the isolated ERα LBD exhibited more potent transcriptional activity than the ERβ LBD.
Although the poorly conserved NTD region clearly plays an important role in isoform-specificity [ 32 33 ] , it is also likely that there are differences in the better conserved LBD region that contribute to differential ERα and ERβ activities.
VP16-ERβ LBD and Gal-ERβ LBD contain human ERβ sequences and were gifts from Dr. Dale Leitmann (University of California, San Francisco).