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Example sentences for: langerhans
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Type 1 diabetes mellitus (T1DM) is a T cell-mediated autoimmune disease characterized by lymphocytic infiltration of the pancreatic islets of Langerhans with subsequent destruction of the insulin-producing beta cells [ 1 ] . Non-obese diabetic (NOD) female mice, a murine model for T1DM, spontaneously develop diabetes by 30 weeks-of-age, with infiltrating cells appearing around the pancreatic islets as early as at 3-4 weeks-of-age [ 2 ] .
Advances in transplant-based therapy for type 1 diabetes mellitus [1] and a dearth of cadaveric pancreatic islets of Langerhans have focused interest on developing renewable sources of transplant-ready islet-replacement tissues.
IL-12, a product of Langerhans cells and skin monocytes plays a pivotal role in T-cell activation that leads to formation of the psoriatic plaque [ 22 ] . IL-12 levels are also significantly raised in patients with Graves' hyperthyroidism and are reduced following treatment with propylthiouracil [ 23 ] .
A full length murine cDNA representing Langerhans cell protein 1 (LCP1) was originally cloned from maturing epidermal Langerhans cells, while its human homologue KIAA0737 was cloned from human brain [ 29 ] as was a cDNA encoding TNRC9 (also known as CAGF9) [ 32 ] . Searches of the EST database confirm that all family members are expressed at the level of mRNA, and we have shown that KIAA0808 is expressed at the level of protein using a cross-reactive anti-TOX antisera (data not shown).
A key element in the generation of the cytokine signals responsible for formation of a psoriatic plaque is the skin antigen-presenting cell or Langerhans cell.
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