Words similar to lacking
Example sentences for: lacking
How can you use “lacking” in a sentence? Here are some example sentences to help you improve your vocabulary:
Abnormal chromosome segregation has been observed in mice lacking the Mad2 checkpoint protein [ 25 ] . The spindle checkpoint utilizes sensory proteins that detect kinetochore-microtubule tension and occupancy and transiently block anaphase until all of the chromosomes are properly attached to microtubules [ 16 26 27 ] . Although the mammalian spindle checkpoint appears to differ between mitosis and meiosis, the two meiotic divisions, and male and female germ cells [ 28 ] , anaphase subsequently follows stable kinetochore-microtubule attachments [ 17 29 ] in both vertebrate mitotic [ 30 ] and meiotic [ 31 ] cells.
While our study suggests that SKP2 is an important player in p27 regulation in prostate cancer cells, recent studies have also implicated another protein, CSN5/JAB1, in p27 regulation [ 54 55 ] . CSN5 is a subunit of the COP9/signalosome (CSN) complex [ 56 57 58 59 ] , but also forms distinct complexes apparently lacking CSN subunits [ 55 60 61 62 ] . Overexpression of CSN5 in NIH3T3 cells causes p27 export from the nucleus and ectopic degradation [ 54 ] . Notably, like SKP2 [ 33 36 37 38 ] , CSN5 was found to be overexpressed in cancers devoid of p27 [ 63 ] . However, our studies did not reveal any effect of MIB on CSN5 expression.
The most basic toxicity tests in animals are lacking for 75% of the 3,000 highest production volume chemicals—chemicals for which annual production exceeds 1 million pounds per year [49,75,76,77].
Lacking heroes, villains, and a moral compass, the first two-thirds of the film leaves you adrift, which means that Hanson and his co-writer, Brian Helgeland ( Conspiracy Theory ) have to absorb you with the force of their storytelling.
Although lacking the associated gene profile, this third group had a survival pattern much like the activated B cell-like group.
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