Words similar to lachesis
Example sentences for: lachesis
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Ethanolic extracts of the aerial parts of Eclipta prostrata (Asteraceae) neutralised the lethal activity of the venom of South American rattlesnake ( Crotalus durissus terrificus ), as well as the myotoxic and haemorrhagic effects of B. jararaca , B. jararacussu and Lachesis muta snake venoms when mixed in vitro before i.p.
Phospholipase A 2 was purified from Lachesis muta venom in Brazil, the venom also showed procoagulant and proteolytic activities [ 33 ] . High proteolytic activity was found in venom of Lachesis muta and no platelet pro-aggregating activity, low inhibitory effect on platelet aggregation and low procoagulant, proteolytic and phospholipase activity for Botrops atrox in Brazil [ 34 ] .
Lachesis muta can inject a large dose of venom in a single bite [ 8 ] . These snakes have front fangs and bitten areas show severe swelling and necrosis of tissue due to haemorrhagic, myotoxic, necrotizing, defibrinogenating, coagulant, caseinolytic, proteolytic, oedema-inducing, coagulant and neurotoxic venom activities [ 8 ] .
The in vitro myotoxicity of the crotalid venoms venoms ( Bothrops jararaca , Bothrops jararacussu and Lachesis muta ) and myotoxins (bothropstoxin, bothropasin and crotoxin) was neutralised by simultaneous exposure of isolated skeletal muscles to an aqueous extract of Eclipta prostrata or to wedelolactone, stigmaterol and sitosterol.
Studies in South America detail the pain and oedema at the bite site and manifestations of autonomic nervous system stimulation (vomiting, diarrhoea, sweating, hypersalivation, bradycardia) that may be attributed to serine protease in Lachesis muta venom which causes hypotension by releasing kinins from plasma kininogen [ 8 ] . There are also cases of bleeding distant from the bite site such as gingival haemorrhage, epistaxis, haemoptysis, haematuria, uterine bleeding, soft tissue haematomas and very infrequently intrathoracic or intrabdominal bleeding [ 35 ] . Complications in the bitten limb can include secondary infections by Gram-negative organisms and acute renal failure among others [ 8 ] . There is a bothrojacarin-like 27 kDa protein in Bothrops species venom [ 36 ] . Bothrojacarin forms a non-covalent complex with thrombin, blocking its ability to induce platelet aggregation and fibrinogen clotting [ 8 36 ] . Haemostatic effects in Lachesis muta venom are attributable to an alpha-fibrin(ogen)ase and haemorrhagic metalloproteinases (LHF-1 and LHF-II) which have alpha-fibrin(ogen)ase activity [ 8 ] .
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