Words similar to labial
Example sentences for: labial
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Yet, the documented expression of the wild-type AR in cultures of these labial cells supports the idea that the AR status of the fibroblast was an important intrinsic determinant of the basal transcription patterns we identified.
One possible interpretation of these data is that the distinct patterns of expression could have been due to differences in the origin or the developmental milieu of foreskin fibroblasts, derived from the genital tubercle, as opposed to the labial fibroblasts, derived from the genital swellings [ 10 ] . The differences in gene expression we observed in AIS fibroblasts of gonadal origin compared to those of labial origin support this view (Figure 3).
Interestingly, fibroblasts derived from abdominal and forearm skin, regions with relatively little sexual dimorphism, showed gene-expression patterns similar to the labial skin fibroblasts of AIS patients.
The ARD364 and ARD465 lines express wild-type AR and were derived from individuals who were mosaics for wild-type AR and AR with a premature stop codon [ 7 ] . Hierarchical cluster analysis, based on the expression of 472 of the 487 previously identified transcripts with measurable expression across at least 80% of 24 experiments, separated the fibroblasts into those with gene-expression patterns resembling normal male foreskin fibroblasts and a second group with an expression pattern more similar to labial skin fibroblasts from AIS-affected individuals (Figure 2).
Gad1 RNA was also detected in some of the posterior labial vibrissae at this stage.
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